Accurate laser skin perforation technique aimed at promoting bleeding and reducing pain

Abstract

Laser skin perforation is an e®ective and promising technique for use in blood collection. In this study, the relation between the perforation pro¯le of skin and laser irradiation at various energies is discussed. Increasing laser energy does not uniformly expand the size and depth of a hole because the shallow depth of¯eld (DOF) of the focused light primarily concentrates energy on the skin surface. In practice, the hole gradually transforms from a semielliptical shape to an upsidedown avocado shape as the laser energy increases. This phenomenon can increase the amount of bleeding and reduce pain. The¯ndings support the feasibility of developing an accurate laser skin perforation method.

In vivo optical monitoring of transcutaneous delivery of calcium carbonate microcontainers

“…Described microablation drug delivery technology has good perspectives for clinical applications also due to recent design of portable and efficient erbium laser devices for tissue microporation [25,26].…”