Nanoparticle tracking analysis, a multi-probe single particle tracking technique, is a widely used method to quickly determine the concentration and size distribution of colloidal particle suspensions. Many popular tools remove non-Brownian components of particle motion by subtracting the ensemble-averaged displacement at each time step, which is termed 'de-drifting'. Though critical for accurate size measurements, de-drifting is shown here to introduce significant biasing error and can fundamentally limit the dynamic range of particle size that can be measured for dilute, heterogeneous suspensions, such as biological extracellular vesicles. We report a more accurate estimate of particle mean-squared displacement, which we call Decorrelation Analysis, that accounts for correlations between individual and ensemble particle motion, which are spuriously introduced by de-drifting. Particle tracking simulation and experimental results show that this approach more accurately determines particle diameters for low concentration, polydisperse suspensions when compared with standard de-drifting techniques.