Accurate performance of a rat model of schizophrenia in the water maze depends on visual cue availability and stability: A distortion in cognitive mapping abilities?

Preissmann, Delphine; Bertholet, Léa; Sierro, Guillaume; Cabungcal, Jan-Harry; Schenk, Françoise

doi:10.1016/j.bbr.2011.04.034

Cited by 6 publications

(4 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This deficit is observed 10 days after cessation of BSO treatment when GSH levels have just returned to the physiological level, but not at the adult age (16). This suggests that early GSH deficit delays the maturation of the circuitry necessary for the successful performance in the water maze (99). At a young adult age (P65 to 90), ODS rats treated with BSO during postnatal early life show impaired memory for familiar objects (22).…”

Section: Fig 2 Hypothesis On the Contribution Of Redox Dysregulatiomentioning

confidence: 99%

Redox Dysregulation in the Pathophysiology of Schizophrenia and Bipolar Disorder: Insights from Animal Models

Kulak

Steullet²,

Cabungcal³

et al. 2013

Antioxidants & Redox Signaling

Self Cite

105

View full text Add to dashboard Cite

show abstract

Section: Fig 2 Hypothesis On the Contribution Of Redox Dysregulatiomentioning

confidence: 99%

Redox Dysregulation in the Pathophysiology of Schizophrenia and Bipolar Disorder: Insights from Animal Models

Kulak

Steullet²,

Cabungcal³

et al. 2013

Antioxidants & Redox Signaling

Self Cite

105

View full text Add to dashboard Cite

show abstract

“…Evaluation of chemically-induced neurotoxicity in laboratory rodents or animal models of several diseases associated with learning and memory decline (e.g., depression, Parkinson disease, senile dementia or brain trauma, schizophrenia, and autism) are frequently expected to test locomotor activity, learning, and memory functions (Fitzgerald, Rosenberg, Oettinger, & Battig, 1985;Vorhees & Williams, 2014;Brown et al, 2012;Chrobal, Hanin, & Walsh, 1987;Hauser, Sontag, Tucha, & Lange, 2012;Preissmann, Bertholet, Sierro, Cabungcal, & Schenk, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Other, more sophisticated methods, such as tasks with touch screen or lever press, require very intensive and long-lasting learning sessions (Brown et al, 2012;Chen, Wong, Chapman, & Pemberton, 2009;de Bruin et al, 2013;Dunnett, Fuller, Rosser, & Brooks, 2012;Nemeth et al, 2002;Preissmann et al, 2011;Sabbagh, Heaney, Bolton, Murtishaw, & Kinney, 2012;Bussey et al, 2008;George, RodriguezSantiago, Riley, & Abelson, 2015).…”

Section: Introductionmentioning

confidence: 99%

Characterization of exploratory activity and learning ability of healthy and “schizophrenia-like” rats in a square corridor system (AMBITUS)

Horváth

Liszli

Kekesi

et al. 2017

Physiology & Behavior

View full text Add to dashboard Cite

The rodent tasks with food rewards are useful methods to evaluate memory functions, including hole-board and corridor tests. The AMBITUS system (a square corridor with several food rewards), as a combination of these tests, was developed for the investigation of a variety of parameters associated with exploration and cognitive performance in rodents. Experiments were performed to characterize these behaviors in healthy rats and a new "schizophrenia-like" rat substrain with impaired learning ability to reveal the reliability in tests related to these functions.A square corridor was constructed with equally spaced sites along each wall (4 inside and 4 outside) resulting in 16 side-boxes for food rewards. Photocells at each box recorded the visits into the side-boxes (as exploratory activity), while the eating parameters were obtained from video records. The animals were exposed to two types of tasks repeatedly in two series: all (16) or only the inside (8) boxes (Task 1 or Task 2, respectively) were baited.Most of the rats acquired Task 1, and their performance improved by repetition, but the new substrain showed decreased exploration and learning capacity. The introduction of Task 2 caused prompt preference of the baited inner side-boxes, and gradually improved working and reference memory during the trials. The manual and automated scoring of the visits into the side-boxes showed significant (r=0.97) correlation.The results proved that healthy animals could perform the simple tasks in the square corridor after a few repetitions. The semi-automated AMBITUS system might be appropriate to detect cognitive flexibility after different manipulations, and it provides immediate, online assessment of exploratory behavior of a large number of animals within a short period of time, and it reduces the possibility of experimenter bias.

show abstract

“…The episodic memory in the explicit memory depends on the hippocampus ( 33 ). The hippocampus is not only closely associated with short-term memory, but also with long-term spatial memory in rats ( 34 ). The water maze assessment was used to determine the spatial memory in the episodic memory.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats

Liu

Zhang

2015

Molecular Medicine Reports

View full text Add to dashboard Cite

The present study aimed to examine the neurophysiological mechanisms of the 2,6-diisopropylphenol and N-methyl-D-aspartate (NMDA) receptor antagonist against learning and memory impairment, induced by electroconvulsive therapy (ECT). A total of 48 adult depressed rats without olfactory bulbs were randomly divided into six experimental groups: i) saline; ii) 10 mg/kg MK-801; iii) 10 mg/kg MK-801 and a course of ECT; iv) 200 mg/kg 2,6-diisopropylphenol; v) 200 mg/kg 2,6-diisopropylphenol and a course of ECT; and vi) saline and a course of ECT. The learning and memory abilities of the rats were assessed using a Morris water maze 1 day after a course of ECT. The hippocampus was removed 1 day after assessment using the Morris water maze assessment. The content of glutamate in the hippocampus was detected using high-performance liquid chromatography. The expression levels of p-AT8Ser202 and GSK-3β1H8 in the hippocampus were determined using immunohistochemical staining and western blot analysis. The results demonstrated that the 2,6-diisopropylphenol NMDA receptor antagonist, MK-801 and ECT induced learning and memory impairment in the depressed rats. The glutamate content was significantly upregulated by ECT, reduced by 2,6-diisopropylphenol, and was unaffected by the NMDA receptor antagonist in the hippocampus of the depressed rats. Tau protein hyperphosphorylation in the hippocampus was upregulated by ECT, but was reduced by 2,6-diisopropylphenol and the MK-801 NMDA receptor antagonist. It was also demonstrated that 2,6-diisopropylphenol prevented learning and memory impairment and reduced the hyperphosphorylation of the Tau protein, which was induced by eECT. GSK-3β was found to be the key protein involved in this signaling pathway. The ECT reduced the learning and memory impairment, caused by hyperphosphorylation of the Tau protein, in the depressed rats by upregulating the glutamate content.

show abstract

Accurate performance of a rat model of schizophrenia in the water maze depends on visual cue availability and stability: A distortion in cognitive mapping abilities?

Cited by 6 publications

References 64 publications

Redox Dysregulation in the Pathophysiology of Schizophrenia and Bipolar Disorder: Insights from Animal Models

Redox Dysregulation in the Pathophysiology of Schizophrenia and Bipolar Disorder: Insights from Animal Models

Characterization of exploratory activity and learning ability of healthy and “schizophrenia-like” rats in a square corridor system (AMBITUS)

Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats

Contact Info

Product

Resources

About