Accurate prediction of the toxicity of benzoic acid compounds in mice via oral without using any computer codes

Keshavarz, Mohammad Hossein; Gharagheizi, Farhad; Shokrolahi, Arash; Zakinejad, Sajjad

doi:10.1016/j.jhazmat.2012.07.048

Cited by 33 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The test sets are particularly poor in detecting chlorinated substances and produce false negative results with a large number of carcinogens with nongenotoxic mechanisms (Mahadevan et al, 2011). Quantitative Structure-Activity Relationships (QSARs) predictive toxicology in recent times has been used not only in molecular design but also to clarify contradicting genotoxicity results Contrera et al, 2007;Keshavarz et al, 2012).…”

Section: Specificitymentioning

confidence: 99%

Toxicity of food colours and additives: A review

Thomas¹,

Adegoke²

2015

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Majority of consumer goods are required to be presented with good aesthetics in order to improve acceptability in terms of colours and in some instances taste. When related to food, beverages and drug products, additives are usually added to mask un-inviting colours, obscure offensive odours and increase taste. Food additives therefore include colourants, sweeteners, preservatives and anti-caking agents. Admissible daily intake limits are often recommended for these additives. Being food products, the amount consumed over time may be subject to individual preferences and thus negating the desire to regulate and control the amount consumed cumulatively. There have been several concerns about the safety of food additives and several batteries of tests, and reports are available in literature. This review attempted to give an update on reports that have surfaced in literature over recent past on the use and safety of food colours and other additives. Some safety concerns have been related to three determinations; cytotoxicity, genotoxicity and induction or potential of inducing mutagenicity. In order to accomplish these targeted evaluations, several tests have been prescribed by International conference on harmonization (ICH), organization for economic co-operation and development (OECD) and European food safety authority (EFSA). It is observed that no single test can give a full proof of safety of these food colours and additives, hence minimal tests are recommended to be carried out in order to guarantee safety of these products. Survey of literature, revealed that once some approved additives or colours become a subject of safety concerns, comprehensive evaluations are carried out by researchers and these have often led to the de-classification of some hitherto reported agents as being non-genotoxic or non-carcinogenic. The declassifications of some food colors and additives as human carcinogens are regularly done following the comprehensive evaluation of results of mutagenicity and genotoxicity tests in vitro and some in vivo tests in mammalian tissues and whole animals. However, such declassifications are often done with caution and the implication is that regular and more comprehensive tests must be carried out. In addition, the requirements of testing for chronic exposures to this and other agents must be emphasized to prevent occurrence of subtle yet terrible side effects resulting from consuming sub-toxic doses of the additives over time.

show abstract

Section: Specificitymentioning

confidence: 99%

Toxicity of food colours and additives: A review

Thomas¹,

Adegoke²

2015

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…There are a limited number of available quantitative structureactivity relationship (QSAR) models for mouse toxicity published in the literature (Raevsky et al, 2010). In comparison with other toxicological endpoints, most QSAR models of mouse acute toxicity by oral administration were specific to one or a small number of classes of chemicals (Tsakovska et al, 2008;Devillers and Devillers, 2009;Lapenna et al, 2010;Bhhatarai and Gramatica, 2011;Keshavarz et al, 2012). A QSAR for the toxicity of 20 pyridines to mice was reported by Cronin et al (2002).…”

Section: Introductionmentioning

confidence: 99%

Relationship between lethal toxicity in oral administration and injection to mice: Effect of exposure routes

Wang

Ning

Tai

et al. 2015

Regulatory Toxicology and Pharmacology

View full text Add to dashboard Cite

“…Sodium benzoate and citric acid ( Figure 1) are food additives which are often combined as preservatives and regulators of acidity in beverage products (Brima and Abbas, 2014;Ciriminna et al, 2017;Penniston et al, 2008). The use of both compounds excessively can cause various side effects such as asthma, urticaria, hyperactivity, renal and hepatic disorders, and tooth enamel damage (Abd-Al Gadir et al, 2009;Chen et al, 2015Chen et al, , 2014Keshavarz et al, 2012;Ren et al, 2009;Shahmohammadi et al, 2016;Shu et al, 2016). Several methods have been used in the analysis of both compounds in beverage products for instance high performance liquid chromatography (HPLC) and mass spectrometry (MS) (Ayorinde et al, 2003;Grembecka et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Chemometrics-assisted spectrophotometry for simultaneous determination of sodium benzoate and citric acid in beverage products

et al. 2018

View full text Add to dashboard Cite

The development and validation of chemometrics-assisted spectrophotometry have been successfully performed for determination of sodium benzoate and citric acid that have overlapping of ultra violet absorption spectra. The study aimed to develop, validate, and apply spectrophotometric method with chemometrics approach for determination of both compounds in beverage products simultaneously. The analytical method was performed by making a calibration model using 16 training sets and 10 test sets of mixed solution followed by absorbance measurenment at wavelength of 190 nm up to 400 nm. In addition, the absorbance data was processed by multivariate calibration models of principal component regression (PCR) and partial least square-1 (PLS-1) and validated internally and externally to obtain optimum model. Validation of analytical methods was done by evaluating some parameters such as linearity and ranges, accuracy, precision, detection limits and quantification limits. The results showed that the optimum wavelength was 235 nm to 250 nm for sodium benzoate and 220 nm to 240 nm for citric acid with the selected optimum principal components (PCs) value were 6 (PCR) and 4 (PLS-1) for sodium benzoate and PCs 2 (PCR and PLS-1) for citric acid. The parameters of the analytical method validation developed were suitable and the analytical methods could be applied for the determination of the sodium benzoate and citric acid contents simultaneously in the beverage products.

show abstract

Accurate prediction of the toxicity of benzoic acid compounds in mice via oral without using any computer codes

Cited by 33 publications

References 32 publications

Toxicity of food colours and additives: A review

Toxicity of food colours and additives: A review

Relationship between lethal toxicity in oral administration and injection to mice: Effect of exposure routes

Chemometrics-assisted spectrophotometry for simultaneous determination of sodium benzoate and citric acid in beverage products

Contact Info

Product

Resources

About