Accurate Staging, Selective Preoperative Therapy and Optimal Surgery Can Deliver a Good Oncological and Functional Outcome in Low Rectal Cancer

Fleming, Fergal J.; Monson, J. R. T.

doi:10.1159/000274466

Cited by 1 publication

(2 citation statements)

References 10 publications

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“…The discrepancy between the threshold found by Yeo et al (16) and that found in our study may be partially explained by the tumor location. In our study, most tumors were low-lying tumors, which are known have poor prognosis and higher risk of recurrence (8)(9)(10). Higher tumoral volume reduction may be crucial in low rectal carcinoma to predict less recurrence.…”

Section: Tumor Volume Regression and Dfsmentioning

confidence: 54%

“…Combined chemotherapy and radiation therapy (CRT) followed by total mesorectal excision have been widely adopted for the management of locally advanced rectal cancers because of their abilities to increase the probability of anal sphincter preservation and decrease the local recurrence rate (6,7). In fact, low rectal tumors are associated with a higher rate of circumferential resection margin (CRM) involvement, higher local recurrence rates, and poorer survival (8)(9)(10) n Tumor volume reduction was an independent prognostic parameter at multivariate analysis (P = .003; 95% CI: 0.01, 0.4). …”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

MR Volumetric Measurement of Low Rectal Cancer Helps Predict Tumor Response and Outcome after Combined Chemotherapy and Radiation Therapy

Nougaret¹,

Rouanet²,

Molinari³

et al. 2012

Radiology

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Purpose To evaluate feasibility of CT colonography (CTC) volumetry of colorectal cancer (CRC) and its correlation with disease stage and patients' survival. Materials and methods CTC volumetry was performed for 126 patients who underwent preoperative CTC. Reproduc-ibility of tumor volume (Tvol) between two readers was assessed. One-way ANOVA and ROC analysis evaluated correlation between Tvol and pTNM staging. ROC analysis compared diagnostic performance to predict pTNM staging between Tvol and radiologist. Kaplan-Meier test compared overall survival. Results Reproducibility among readers was excellent (interclass correlation = 0.9829). Mean Tvol showed an incremental trend with T stage and Tvol of pT4b stage was significantly larger than other stages (P<0.0001). Az value (0.780) of Tvol to predict pT4b stage was significantly larger than that (0.591) of radiologist (P = 0.004). However, Tvol was not significantly different according to pN stage. Az values (0.723~0.857) of Tvol to predict M1 or M1b were comparable to those (0.772~0.690) of radiologist (P>0.05). Smaller tumor burden (12.85cm 3), T3, N0, M0 stages, and curative surgery were significantly associated with patients' longer survival (P<0.05).

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