ACE gene polymorphism in childhood IgA nephropathy: Association with clinicopathologic findings

Tanaka, Ryojiro; Iijima, Kazumoto; Murakami, Ryusuke; Koide, Masaaki; Nakamura, Hajime; Yoshikawa, Norishige

doi:10.1016/s0272-6386(98)70045-9

Cited by 37 publications

(27 citation statements)

References 34 publications

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“…However, we found no association between the presence of hypertension and ACE polymorphism in our patients. This is in agreement with earlier reports on ACE polymorphism and blood pressure in patients with IgAN [9, 12, 13]. Nor did we find any association between ACE genotypes and other cardiovascular risk factors which accords with an earlier study on the effect of ACE polymorphism in diabetic nephropathy [24].…”

Section: Discussionsupporting

confidence: 93%

“…The genotype frequency in our patients was similar to that in the Finnish population in general [21]. This is in accordance with previous results, where no differences have been found in genotype frequency in IgAN patients as compared with healthy subjects [9, 10, 12, 13, 14]. Recent studies have yielded conflicting results on the association between ACE gene polymorphism and the prognosis of IgAN.…”

Section: Discussionsupporting

confidence: 91%

“…Similarly, there are studies showing an association between ACE gene polymorphism and a poor prognosis of IgAN [8, 9, 10, 11]. ACE gene polymorphism has not been found to influence the likelihood of developing IgAN [9, 10, 12], but ACE genotype DD or the presence of the D allele has been associated with a poor outcome [8, 9, 10, 11], although opposite results have also been reported [13, 14, 15]. Therefore, the influence of ACE gene polymorphism on the progression of IgAN is still debated.…”

Section: Introductionmentioning

confidence: 99%

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Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Prognosis of IgA Nephropathy

Syrjänen

Xiao-hong²,

Mustonen³

et al. 2000

Nephron

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Background/Aim: Well-known factors for a poor prognosis in IgA nephropathy (IgAN) are hypertension, proteinuria, and renal insufficiency at the time of diagnosis. Also hypertriglyceridemia and hyperuricemia seem to play a role in the progression of IgAN. Angiotensin-converting enzyme (ACE) gene I/D polymorphism has been associated with cardiovascular diseases and with progression of IgAN. We, therefore, investigated the contribution of ACE gene I/D polymorphism in the prognosis of IgAN and its association with the other risk factors affecting the prognosis. Methods: A total of 168 patients with IgAN were followed up for 6–17 (median 11) years from renal biopsy with respect to progression of renal disease defined as elevation of serum creatinine above 125 µM (1.4 mg/dl) in men or 105 µM (1.2 mg/dl) in women and over 20% from the baseline level. In addition to serum creatinine, the urinary protein excretion was evaluated at the time of renal biopsy and at the assessment visit at the end of the follow-up period. Results: During the follow-up period, 26 (15%) patients showed progression of renal disease. Patients with ACE genotype II had a more favorable course than those with genotypes ID or DD. Although there were no significant differences among the ACE genotypes with respect to proteinuria ≧1 g/24 h at the time of renal biopsy, proteinuria ≧1 g/24 h was more frequent in patients with genotypes ID or DD than in those with genotype II at the end of the follow-up period. No associations were found between hypertension, serum lipids or serum urate, and ACE genotypes. Conclusions: Our results show that patients with ACE genotype II have a more favorable prognosis than those with genotypes ID/DD. Secondly, proteinuria (≧1 g/24 h) found in patients with genotype II at diagnosis may improve, while in patients with genotypes ID/DD it is a more constant feature.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Prognosis of IgA Nephropathy

Syrjänen

Xiao-hong²,

Mustonen³

et al. 2000

Nephron

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“…Third, it was reported that PCR amplification using only flanking primer pairs would misclassify 4–5% of the ID genotype as the DD genotype [17]. Therefore, 6 studies without a second PCR to confirm the DD genotype were also excluded [30,31,32,33,34,35]. Furthermore, 1 study was excluded to avoid inclusion of duplicated data as the same patients and controls seemed to be reported in both studies [16, 36].…”

Section: Resultsmentioning

confidence: 99%

Association of Angiotensin I-Converting Enzyme Gene Insertion/Deletion Polymorphism and IgA Nephropathy: A Meta-Analysis

Du¹,

Qing²,

Liu³

et al. 2006

Am J Nephrol

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Background/Aims: The angiotensin I-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been extensively examined for the association with immunoglobulin A (IgA) nephropathy (IgAN), however, conflicting results have occurred. We performed a meta-analysis to evaluate the association of ACE I/D polymorphism with IgAN in different ethnic groups. Methods: 11 studies testing the association between ACE I/D polymorphism and IgAN susceptibility, and 9 studies testing the association of ACE I/D with IgAN progression were used in this analysis. The overall odds ratio (OR) was estimated by a fixed or random effect model. Results: The overall OR for the risk of susceptibility and progression of IgAN in Asians for the DD genotype is 2.37 (95% CI 1.04–5.41) and 1.75 (95% CI 1.24–2.56). The overall OR for the D allele in Asians also showed a similar magnitude, though without statistical significance (p = 0.09, p = 0.13, respectively). In Caucasians, both the DD genotype and D allele were associated with IgAN progression (OR 1.90, 1.61, respectively), but not IgAN susceptibility (p = 0.30, p = 0.41, respectively). Conclusion: Our findings support the notion that ACE I/D polymorphism is associated with IgAN. Meanwhile, the role of ACE I/D polymorphism in Asians is different from that of Caucasians.

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“…Recent findings indicate that the DD genotype of the angiotensin-converting enzyme gene is associated with a more rapid decline of the renal function [29, 30]. Recently, we demonstrated that the D allele of the angiotensin-converting enzyme gene is associated with heavy proteinuria and severe glomerular changes [31]. Such genetic influences might underlie abnormal lymphocyte function in patients with IgA nephropathy as well as in their relatives [32].…”

Section: Epidemiologymentioning

confidence: 99%

IgA Nephropathy in Children

Yoshikawa¹,

Iijima

Ito

1999

Nephron

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ACE gene polymorphism in childhood IgA nephropathy: Association with clinicopathologic findings

Cited by 37 publications

References 34 publications

Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Prognosis of IgA Nephropathy

Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Prognosis of IgA Nephropathy

Association of Angiotensin I-Converting Enzyme Gene Insertion/Deletion Polymorphism and IgA Nephropathy: A Meta-Analysis

IgA Nephropathy in Children

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