ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension

Ali, Ahmed; Alghasham, Abdullah; Ismail, Hisham; Dowaidar, Moataz; Settin, Ahmad

doi:10.1177/1470320312459976

Cited by 30 publications

(29 citation statements)

References 48 publications

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“…Also the recessive model (DD versus II+ID) showed an association with hypertension with an adjusted odds ratio of II+ID 1.79(95% CI: 1.09-2.92) (data not shown in Table 4), indicating that the ACE gene I/D polymorphism appeared strong evidence to support the role of the D-allele and/or DD genotype as a risk factor for hypertension. These findings are in agreement with those of Ahmad Ali [2], who noted that hypertensive cases showed a significantly higher frequency of the ACE mutant D allele carriage than I allele carriage. Also, Zarouk et al [1] reported that DD genotype and the D allele are significantly associated with hypertension in Egyptian patients, A significant association between the I/D variant and hypertension was also found among Han Chinese through recent meta-analysis [3].…”

Section: Discussionsupporting

confidence: 93%

Associations of ACE Gene Insertion/Deletion Polymorphism, ACE Activity, and ACE mRNA Expression with Hypertension in a Chinese Population

Fan

et al. 2013

PLoS ONE

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BackgroundThe present study was designed to explore the association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D, rs4646994) polymorphism, plasma ACE activity, and circulating ACE mRNA expression with essential hypertension (EH) in a Chinese population. In addition, a new detection method for circulating ACE mRNA expression was explored.MethodsThe research was approved by the ethics committee of Zhejiang Provincial Center for Disease Prevention and Control. Written informed consent was obtained prior to the investigation. 221 hypertensives (cases) and 221 normotensives (controls) were interviewed, subjected to a physical examination, and provided blood for biochemical and genetic tests. The ACE mRNA expression was analyzed by real time fluorescent quantitative Reverse Transcription PCR (FQ-RT-PCR). We performed logistic regression to assess associations of ACE I/D genotypes, ACE activity, and ACE mRNA expression levels with hypertension.ResultsThe results of the multivariate logistic regression analysis showed that the additive model (ID, DD versus II) of the ACE genotype revealed an association with hypertension with adjusted OR of 1.43(95% CI: 1.04-1.97), and ACE ID genotype with adjusted OR of 1.72(95% CI: 1.01-2.92), DD genotype with adjusted OR of 1.94(95% CI: 1.01-3.73), respectively. In addition, our data also indicate that plasma ACE activity (adjusted OR was 1.13(95% CI: 1.08-1.18)) was significantly related to hypertension. However, the plasma ACE mRNA expressions were not different between the cases and controls.ConclusionACE I/D polymorphism and ACE activity revealed significant influence on hypertension, while circulating ACE mRNA expression was not important factors associated with hypertension in this Chinese population. The detection of circulating ACE mRNA expression by FQ-RT-PCR might be a useful method for early screening and monitoring of EH.

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Section: Discussionsupporting

confidence: 93%

Associations of ACE Gene Insertion/Deletion Polymorphism, ACE Activity, and ACE mRNA Expression with Hypertension in a Chinese Population

Fan

et al. 2013

PLoS ONE

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“…A study of a Saudi population noted a higher frequency of the mutant deletion allele in hypertensive cases with a BMI of ≥30 kg/m 2 in comparison to controls, although the difference was not significant. 20 However, this result was reversed in the current study, as the frequency of the deletion allele among the hypertensive overweight/obese group was significantly lower than the control group. A similar study performed on Korean women also confirmed this finding (P = 0.063).…”

Section: Discussioncontrasting

confidence: 46%

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Rizvi

Raza

Siddiqi

et al. 2015

SQUMJ

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abstract:Objectives: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. Methods: This case-control study was carried out between May 2013 and November 2014 at the Era's Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (<25 kg/m 2 ) or high (≥25 kg/m 2 ) BMI. The third group consisted of 125 age-, gender-and ethnically-matched normotensive controls with a normal BMI. Gene polymorphisms were evaluated by polymerase chain reaction. The genotypic and allelic frequency distribution among both groups were analysed. Results: A significant difference was found between GST theta 1-null and GST mu 1-positive genotype frequencies among the hypertensive overweight/obese individuals and controls (P = 0.014 and 0.033, respectively). However, no difference was observed in the frequency of ACE polymorphisms. ACE insertion/insertion genotype (P = 0.006), insertion and deletion alleles (P = 0.007 each) and GST theta 1-null and GST theta 1-positive genotypes (P = 0.006 each) were found to differ significantly between hypertensive cases and controls, regardless of BMI. Conclusion: ACE and GST gene polymorphisms were not associated with BMI but were significantly associated with hypertension among the studied group of North Indians.

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“…Study conducted by He et al on Chinese population suggested that the ACE D allele was significantly associated with hypertension (31). Also, Ahmad Ali's study confirmed these results and noted that hypertensive cases have significantly higher frequency of the ACE mutant D allele carriers than I allele carriers (32). In association to the elite sport performance, it is well known that RAAS plays an important role in the regulation of myocardial growth, by increasing of plasma Ang II concentrations, leading to left ventricular hypertrophy (33).…”

Section: The Frequency Of Ace I/d Polymorphism In General Population mentioning

confidence: 72%

The angiotensin converting enzyme (ace) gene polymorphism: Insight study of the renal regulation of the arterial blood pressure

Durmic¹,

Mihailovic²,

Zdravković³

et al. 2016

Med podmladak

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Since the renin-angiotensin-aldosterone system (RAAS) was originally described, it has become one of the best described hormonal systems, especially regarding the fact that it plays an important role in regulating blood volume and systemic vascular resistance, and thus indirectly influencing blood pressure (BP). On the other hand, arterial hypertension is one of the most pertinent disorders which plays an important role, not only in the progression of renal failure, but also represents a risk factor for the occurrence of end stage renal disease. Several epidemiological studies pointed out the fact that genetic predisposition accounts for about 30% of the BP variability. Up to date, there are several RAAS genes that may have effect in long-term BP control, but ACE is the most important and the most thoroughly examined. In this review, we present available data regarding the influence of gene polymorphisms of ACE on its function, within the RAAS related BP regulation. Therefore, by specially describing all its potential physiological roles, it will likely offer a new insight in the renal regulation of the BP, along with its other, not less important, roles.

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ACE I/D and eNOS E298D gene polymorphisms in Saudi subjects with hypertension

Abstract: There is increased frequency of ACE and eNOS mutant allele carriage among Saudi patients affected with hypertension, particularly if accompanied by obesity and diabetes.

Cited by 30 publications

References 48 publications

Associations of ACE Gene Insertion/Deletion Polymorphism, ACE Activity, and ACE mRNA Expression with Hypertension in a Chinese Population

Associations of ACE Gene Insertion/Deletion Polymorphism, ACE Activity, and ACE mRNA Expression with Hypertension in a Chinese Population

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

The angiotensin converting enzyme (ace) gene polymorphism: Insight study of the renal regulation of the arterial blood pressure

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