2013
DOI: 10.1016/j.jaip.2013.07.005
|View full text |Cite
|
Sign up to set email alerts
|

ACE Inhibitor–Induced Angioedema

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
33
0
3

Year Published

2014
2014
2024
2024

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 43 publications
(36 citation statements)
references
References 25 publications
0
33
0
3
Order By: Relevance
“…For ACE inhibitor-induced AE, which occurs more frequently in African Americans in the USA, elevated levels of bradykinin are thought to be due to decreased catabolism of bradykinin as a result of a defect in kininase II, an enzyme which normally controls bradykinin levels [12]. In addition, aminopeptidase P (APP) degrades des-Arg9-BK, an active metabolite of bradykinin that binds to bradykinin1 receptors during inflammation, which may also result in increased bradykinin levels and lead to AE [13].…”
Section: Pathophysiologymentioning
confidence: 99%
“…For ACE inhibitor-induced AE, which occurs more frequently in African Americans in the USA, elevated levels of bradykinin are thought to be due to decreased catabolism of bradykinin as a result of a defect in kininase II, an enzyme which normally controls bradykinin levels [12]. In addition, aminopeptidase P (APP) degrades des-Arg9-BK, an active metabolite of bradykinin that binds to bradykinin1 receptors during inflammation, which may also result in increased bradykinin levels and lead to AE [13].…”
Section: Pathophysiologymentioning
confidence: 99%
“…Figure 2B depicts the tongue swelling after a lack of response to the icatibant. A diagnosis of idiopathic angio-oedema was made after complement levels were found to be normal, with no response to medical therapy 1. The swelling resolved within a month of discharge after no further treatment.…”
Section: Descriptionmentioning
confidence: 99%
“…Angio-oedema can be categorised as allergic (IgE medicated) or non-allergic (bradykinin mediated) 1. ACE inhibitor induced angio-oedema is bradykinin dependent, which probably explains why the first patient responded to icatibant while the second patient did not 2.…”
Section: Descriptionmentioning
confidence: 99%
See 1 more Smart Citation
“…This explains the poor response to treatment with classical antiallergic drugs, which instead act on histamine-related pathways [3,9,10]. The treatment of ACEI-AAE may, therefore, rely upon drugs exerting an antagonist effect towards bradykinin or targeting the kallikrein-kinin system [11][12][13]. Unfortunately, at present there are no specific drugs registered for the treatment of this form of angioedema.…”
Section: Introductionmentioning
confidence: 99%