ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway

Li, Ya; Wan, Tian-Tian; Li, Jia-Xin; Xiao, Xue; Liu, Lei; Li, Hui-Hua; Guo, Shu-Bin

doi:10.1007/s12035-024-04063-1

Mol Neurobiol

2024

DOI: 10.1007/s12035-024-04063-1

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ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway

Ya Li,

Tian-Tian Wan,

Jia-Xin Li

et al.

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Cited by 3 publications

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Review on the Role of Mitochondrial Dysfunction in Septic Encephalopathy

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International Immunopharmacology

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The Role of ACE2 in Neurological Disorders: From Underlying Mechanisms to the Neurological Impact of COVID-19

Li,

Kong,

Liu

et al. 2024

IJMS

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Angiotensin-converting enzyme 2 (ACE2) has become a hot topic in neuroscience research in recent years, especially in the context of the global COVID-19 pandemic, where its role in neurological diseases has received widespread attention. ACE2, as a multifunctional metalloprotease, not only plays a critical role in the cardiovascular system but also plays an important role in the protection, development, and inflammation regulation of the nervous system. The COVID-19 pandemic further highlights the importance of ACE2 in the nervous system. SARS-CoV-2 enters host cells by binding to ACE2, which may directly or indirectly affect the nervous system, leading to a range of neurological symptoms. This review aims to explore the function of ACE2 in the nervous system as well as its potential impact and therapeutic potential in various neurological diseases, providing a new perspective for the treatment of neurological disorders.

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ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway

Cited by 3 publications

References 53 publications

Review on the Role of Mitochondrial Dysfunction in Septic Encephalopathy

Review on the Role of Mitochondrial Dysfunction in Septic Encephalopathy

Macrophage polarization in sepsis: Emerging role and clinical application prospect

The Role of ACE2 in Neurological Disorders: From Underlying Mechanisms to the Neurological Impact of COVID-19

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