Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices

Abstract

The current study is aimed at developing Plantago ovata F. husk mucilage (PHM)‐blended Zn2+‐crosslinked low methoxyl (LM) pectinate (PHM‐Zn2+‐LM‐pectinate) controlled‐release matrices containing aceclofenac (ACF) for the management of rheumatoid arthritis (RA) in patients with an outright zinc deficiency. The ACF‐encapsulated hydrogel matrices are accomplished by ionic gelation using ZnSO4 as a crosslinker. The matrix diameter ranges from 1.39 ± 0.14 to 1.62 ± 0.16 mm. These formulations demonstrate excellent drug encapsulation efficiency (DEE, 63.80 ± 1.73–90.56 ± 2.72%) and controlled drug‐release behavior over a prolonged period of time (Q10 h, 51.42 ± 3.10 to 92.60 ± 2.38%). The drug‐elution patterns of different matrices are best‐fitted by a zero‐order kinetic model with a case‐II‐transport‐driven mechanism. The matrices also depict pH‐dependent swelling and degradation properties. In addition, the composites are characterized by scanning electron microscopy (SEM), Fourier transform IR (FTIR), and powder X‐ray diffraction (P‐XRD) analyses. Thus, the newly developed PHM‐Zn+2‐LM‐pectinate matrices could be appropriate for controlled ACF delivery along with Zn supplementation in the effective treatment of RA.

Preparation and evaluation of aceclofenac dental pastes using dillenia fruit gum for periodontitis treatment

“…Chemically, it is 2-[(2′, 6′-dichlorophenyl) amino] phenylacetoxyacetic acid [30]. It is widely used in the management of pain and inflammation [31,32]. Aceclofenac is also reported to reduce the dental pain and inflammation [33].…”

Chondroitin: a natural biomarker with immense biomedical applications

“…Various enzymes, such as N-acetylgalactosamine transferase, Dglucuronic acid transferases, chondroitin synthases, CS N-acetylgalactosaminyl transferases (I & II), CS glucuronyl transferase and CS polymerization factor, catalyze proper co-ordination during chain elongation by phosphorylation or sulfation reactions; however, no single enzyme can develop the total chondroitin sulphate chain. 12,13 Another set of enzymes, such as chondroitin-4-sulfotransferase, chondroitin-6-sulfotransferase or GalNAc-4 sulfate 6-O-sulfotransferase, are necessary for sulfation reactions in N-acetylgalactosamine residues, respectively. 14,15 3.…”

Formulation and ex vivo skin permeation of lidocaine HCl topical gels using dillenia (Dillenia indica L.) fruit gum

“…Nowadays, naturally occurring polysaccharides are getting important role in the preparation of different type of drug delivery systems as the excepient and coating materials (Nayak et al, 2017Milivojevic et al, 2019;Bera et al" 2019;Dey et al, 2019;Samanta et al, 2019;Ansari et al, 2019;Guru et al, 2018;Serrano-Niño et al, 2020;De la Mora-López et al, 2018;Flores-Martinez et al, 2016;Medrano de Jara et al, 2020;López-Hernández et al, 2018). Dillenia fruit gum (DG) is obtained from ripe dellinia (Dillenia indica L., family: Dilleniaceae) fruits (Sahu et al, 2011).…”