Acellular bioactivity and drug delivery of new strontium doped bioactive glasses prepared through a hydrothermal process

Abstract

This work aims to study the kinetics of apatite layer formation on the surface of strontium doped binary bioactive glasses (BG: 63S37C) prepared by a hydrothermal process and evaluate their potential for drug loading and release.

Tailored electrophoretic coatings for enhanced corrosion resistance of 316L stainless steel implants using bioactive glasses

“…The synthesis was performed as described previously 25,26 with slight modifications. Glasses 15-805P and 15-7510P (Table 2) were synthesized hydrothermally.…”

“…The study also examined the effect of chitosan on BGs nanoparticle suspension preparation, coating bioactivity, and electrochemical behavior in the SBF medium. The synthesis was performed as described previously 25,26 with slight modifications. Glasses 15-805P and 15-7510P (Table 2) were synthesized hydrothermally.…”

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

“…Bioactive ceramics hydroxyapatites coatings on metallic implants [177][178][179] fluorapatite-based composites bone applications [180] bioactive glasses bone substitute and drug carrier [181] bioactive glass ceramics chemo hyperthermia [182] Biodegradable (bioresorbable)ceramics aluminium-calcium phosphate biomedical application [183] zinc-calcium phosphorous oxides postoperative tumour treatment [184] zinc-sulfate-calcium phosphates tissue engineering [185] ferric-calcium phosphorous oxides scaffolding for cell and drug delivery [186] coralline drugs [187] calcium aluminates bioactive dental materials [188] Bioinert (nonresorbable) ceramics alumina drug delivery [189] zirconia biomedical applications [190] carbons biomedical applications for tissue engineering [191] silicon nitride biomedical applications in medical implants [192]…”

Influence of Strontium on the Biological Behavior of Bioactive Glasses for Bone Regeneration

“…Diverse methods has been reported in the literature for the synthesis of bioactive glass powders, fibers and scaffolds. Among them, we can mention melt quench [38,39], which consists of the fusion of oxides and subsequent tempering in a graphite mold or water; sol-gel [40][41][42], in which precursors are added to a solution for the hydrolysis step, then the sample is condensed and the colloidal sol is produced, with the gelation process occurring a few hours later; hydrothermal processes [43,44], which consist of a closed system containing the heterogeneous solution under high temperature and in the presence of aqueous solvent and pressure; electrospinning [45][46][47]; and solution blow spinning [48]. In the first process, a solution is subjected to an electrical charge, overcoming surface tension, and producing a jet of fluid that allows the evaporation of the solvent and results in fibers deposited in a collector.…”

“…After immersing the BG with 6 mol% Sr 2+ in SBF for 7 days, a nanostructured hydroxyapatite layer on the surface was formed, increasing the BG biomineralization ability. Furthermore, El Baakili et al [43] studied the kinetics of the formation of the apatite layer on the surface of binary bioactive glasses (63SiO 2 -(37 − x)CaO-xSrO) doped with Sr 2+ (x = 0.2-1 mol%) and prepared via a hydrothermal process. Their results highlighted the positive effect of Sr incorporation on BG biomineralization due to its physical and chemical similarity with calcium ions, showing a greater formation of the apatite layer on the surface of the material.…”