Acellular Dermal Matrix as a Membrane for Guided Tissue Regeneration in the Treatment of Class II Furcation Lesions: A Histometric and Clinical Study in Dogs

Andrade, Patrícia Freitas de; Souza, Sérgio Luı́s Scombatti de; Macedo, Guilherme de Oliveira; Novaes, Arthur B.; Grisi, Márcio Fernando de Moraes; Taba, Mário; Palioto, Daniela Bazan

doi:10.1902/jop.2007.060325

Cited by 35 publications

(35 citation statements)

References 42 publications

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“…In similar defects, Andrade, et al 1 (2007) observed a correlation between the exposure of the membrane and the epithelial migration. The presence of epithelial tissue was observed in all histological sections of the sites that shown a membrane exposure and was ascribed to the degradation of the exposed portions of this material.…”

Section: Discussionmentioning

confidence: 87%

Platelet-rich plasma in the treatment of Class II furcation defects: a histometrical study in dogs

et al. 2012

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Objective This study was designed to evaluate the potential adjunctive benefits of platelet-rich plasma (PRP) when used with guided-tissue regeneration (GTR) and bioactive glass (BG) in the treatment of Class II furcation lesions. Material and Methods Bilateral Class II furcation lesions were surgically created and allowed to become chronic in the mandibular third premolars of 9 dogs. The defects were randomly assigned to: A) GTR+BG and B) GTR+BG+PRP. Similar defects were created in the maxillary third premolars and received the same treatments after 45 days. Dogs were sacrificed 90 days after the first treatment. The histometric parameters evaluated were: connective tissue adaptation, new cementum, new bone, mineralized bone area, non-mineralized bone area, and residual BG particle area. Results Data analysis showed a superior length of new cementum and a greater mineralized bone area for group B in both periods (p<0.05). The non-mineralized bone area was greater in the control group (p<0.05) in both periods. Conclusion Within the limits of this study, it can be concluded that the use of PRP in the treatment of Class II furcation defects may enhance the amount of new cementum and provide a more mineralized bone in a shorter period of time.

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Section: Discussionmentioning

confidence: 87%

Platelet-rich plasma in the treatment of Class II furcation defects: a histometrical study in dogs

et al. 2012

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“…After carefully removing the anesthesia needle, the penetration depth was measured with a caliper with a 0.05‐mm resolution 18 . The clinical measurements of WKT and TKT were performed three times by the same examiner (DMR), and the mean from these three values was calculated to represent WKT and TKT, respectively 18,34 . The time between the measurements was ≈10 minutes.…”

Section: Methodsmentioning

confidence: 99%

Comparison Between Micro‐ and Macrosurgical Techniques for the Treatment of Localized Gingival Recessions Using Coronally Positioned Flaps and Enamel Matrix Derivative

Andrade

Grisi

Marcaccini

et al. 2010

Journal of Periodontology

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“…Histological and clinical studies have reported the potential of guided tissue regeneration (GTR) to regenerate periodontal ligament, cementum and alveolar bone (2,3), and the technical reasons for the success of this technique are well described in literature (4). In GTR, a barrier is inserted between the root surface and the gingival tissues to inhibit the apical migration of the epithelium and gingival connective tissue of the flap, allowing the granulation tissue derived from the periodontal ligament and osseous tissues to repopulate the space adjacent to the denuded root surface.…”

Section: Introductionmentioning

confidence: 99%

Effect of Early Membrane Removal on the Treatment of Mandibular Class II Furcation Defects - A Controlled Clinical Trial with Re-entry after 12 Months

et al. 2013

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In a previous study in dogs, the early removal of expanded polytetrafluoroethylene (ePTFE) membrane (2 weeks after placement) showed histomorphometric results (of new bone, cementum and periodontal ligament) similar to that obtained with membrane removal at 4 weeks after placement. This study evaluated the influence of early removal of an ePTFE membrane on the treatment of Class II furcation defects. Twelve patients who provided 12 pairs of mandibular furcation defects were recruited for the study. Baseline clinical measurements were recorded: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), gingival margin position (GMP) and relative clinical attachment level (RCAL). Full flaps were elevated and hard tissue measurements were performed during the surgery: relative vertical (RVBL) and horizontal (RHBL) bone level. The ePTFE membranes were adapted and sutured to their correspondent tooth and removed at 2 weeks in the test group (TGr) and at 4 weeks in the control group (CGr). After 1 year all sites were re-entered, and soft and hard tissue measurements were recorded. There were no statistically significant differences between TGr and CGr for any baseline measurement. After 12 months, there were no statistically significant differences between TGr and CGr in the PD (p=0.74), GMP (p=0.76) and RCAL (p=0.44) values. However, the RHBL resolution was significant for both groups (CGr p=0.01 and TGr p=0.02), without difference between groups (p=0.39). Early removal of membranes did not affect the outcome on the treatment of Class II furcation defects.

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Acellular Dermal Matrix as a Membrane for Guided Tissue Regeneration in the Treatment of Class II Furcation Lesions: A Histometric and Clinical Study in Dogs

Abstract: The ADM demonstrated histomorphometric results similar to the bioabsorbable membrane and resulted in a greater increase in the thickness of the keratinized tissue.

Cited by 35 publications

References 42 publications

Platelet-rich plasma in the treatment of Class II furcation defects: a histometrical study in dogs

Platelet-rich plasma in the treatment of Class II furcation defects: a histometrical study in dogs

Comparison Between Micro‐ and Macrosurgical Techniques for the Treatment of Localized Gingival Recessions Using Coronally Positioned Flaps and Enamel Matrix Derivative

Effect of Early Membrane Removal on the Treatment of Mandibular Class II Furcation Defects - A Controlled Clinical Trial with Re-entry after 12 Months

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