Acemannan Induced Bone Regeneration in Lateral Sinus Augmentation Based on Cone Beam Computed Tomographic and Histopathological Evaluation

Abstract

Acemannan, the major polysaccharide extracted from Aloe vera, is biomaterial that has demonstrated osteoinductive effects in vitro and in vivo. However, the effect of acemannan sponges on bone formation in open-type sinus augmentation has not evaluated. Here, we report a case study using radiographic and histological analyses to investigate the effect of acemannan on bone formation after lateral sinus lift surgery. The case was a 57-year-old female patient with an atrophic left posterior maxilla who underwent lateral sinus lift using an acemannan sponge using the two-stage procedure. In the first stage, an acemannan sponge was inserted through the bony window and placed between the antral floor and the elevated sinus membrane. Cone beam computed tomography (CBCT) images were taken immediately as baseline and 6-month postoperation for evaluation. A bone core specimen was also obtained for histological examination at the time of implant placement. The histological results revealed new bone formation, and the CBCT images demonstrated increased alveolar bone height at 6-month postoperation. Our findings suggest that an acemannan sponge could be a biomaterial for inducing bone formation in sinus lift surgery.

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

“…In addition, aloe-emodin has been documented to ameliorate renal interstitial fibrosis (32), whilst aloin demonstrated selective effects against Leishmania aethiopica and Leishmania donovani (33) and isovitexin was indicated to be an anti-diabetic (34,35) and neuroprotective (36) compound. Acemannan may also be used as a matrix for bone regeneration (37)(38)(39).…”

Pulse Oximetry and Three-Dimensional Analysis in Evaluating Immature Permanent Teeth Apexogenesis: Two Case Reports

“…The healthy pulp was flushed with 2% NaOCl, and hemostasis was obtained by placing moist cotton pellets over the pulp stumps (2 min light pressure). An acemannan sponge (1 mg in a 2.5x2.5x2 mm 3 ) was prepared as previously described [5], and gently placed over the remaining healthy pulp. The cavity was lined with glass ionomer cement (Base cement, Shofu, Japan) and restored with a permanent composite restoration (Filtek Z350XT, 3M ESPE, St Paul, MN, USA).…”

Applications of Finite Element in Implant Dentistry and Oral Rehabilitation

“…The amount and quality of the bone play a vital role in the successful rehabilitation of edentulous maxilla using implants. An inadequate bone may be caused due to various reasons resulting in bone resorption [20,21]. Sinus lift is used commonly in bone thickness is below 2-3 mm and the patient requires bone augmentation procedures [20,22].…”