Acetaminophen and childhood asthma: Pill-popping at our peril?

Shaheen, Seif O.

doi:10.1016/j.jaci.2014.10.030

Cited by 7 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was a consistent significant association in our study between current and severe asthma with monthly paracetamol consumption as also reported in other studies . Paracetamol when consumed, causes the total glutathione levels rise and this has been associated with marked functional bronchoconstriction .…”

Section: Discussionsupporting

confidence: 92%

“…There was a consistent significant association in our study between current and severe asthma with monthly paracetamol consumption as also reported in other studies. [46][47][48] Paracetamol when consumed, causes the total glutathione levels rise and this has been associated with marked functional bronchoconstriction. 48 These levels are reported to be increased in induced sputum of patients with mild and moderate asthma, 46 further buttressing the contribution of oxidative stress to the pathogenesis of airway inflammation.…”

Section: Many Households In Low and Middle-income Countries Burnmentioning

confidence: 99%

See 1 more Smart Citation

Environmental risk factors for asthma in 13‐14 year old African children

Ayuk

Ramjith

Zar

2018

Pediatric Pulmonology

View full text Add to dashboard Cite

Background Asthma prevalence in African children is high. Factors driving the prevalence or disease severity are poorly understood. This study aims to investigate environmental factors associated with asthma and severity in African children. Methods Population based cross‐sectional study of children aged 13–14 years from 10 African centers who participated in ISAAC III. Self‐reported environmental exposures included engaging in physical exercise, television watching, various biomass and ETS exposure, consumption of paracetamol, large family sizes and having pets in the home. Univariable and multivariable analyses were done adjusting for center variations. Prevalences, odds ratio and 95% confidence intervals (CI) were calculated. Results There were 258 267 children recruited among the 13‐14‐year‐old participants. Of these, 28,391 respondents from 232 schools completed both the written questionnaire (WQ) and environmental questionnaire (EQ). The prevalence of asthma and severe asthma were 12.8% (CI 12.4‐13.2), and 8.7% (CI 8.4‐8.0) respectively. Factors strongly associated with asthma were maternal smoking (OR = 1.41; 95%CI: 1.23‐1.64), open fire heating (OR = 1.28; 95%CI: 1.08‐1.51) electric heating (OR = 1.13; 95%CI: 1.01‐1.28), physical exercise (OR = 1.29; 95%CI: 1.11‐1.50), monthly paracetamol use (OR 1.23; 95%CI 1.13‐1.33), having an elder sibling (OR = 0.87; 95%CI 0.77‐0.98). Factors associated with severe asthma were maternal smoking (OR = 1.61; 95%CI: 1.38‐1.89), cat pet (OR = 1.14; 95%CI: 1.04‐1.25), frequent physical exercise (OR = 1.42; 95%CI: 1.23‐1.64) and monthly paracetamol use (OR = 1.20; 95%CI 1.07, 1.34). Conclusion Several environmental exposures were associated with asthma and severe disease.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Many Households In Low and Middle-income Countries Burnmentioning

confidence: 99%

Environmental risk factors for asthma in 13‐14 year old African children

Ayuk

Ramjith

Zar

2018

Pediatric Pulmonology

View full text Add to dashboard Cite

show abstract

“…Frequent use of paracetamol may be one of risk factors for developing these conditions. However, researchers agree that well designed clinical trials and cohort studies are needed to determine such a correlation and dispel the doubts [24,33,34].…”

Section: Discussionmentioning

confidence: 99%

The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population

Lipiec¹,

Wawrzyniak²,

Sybilski³

et al. 2018

Ann Agric Environ Med.

View full text Add to dashboard Cite

show abstract

“…Meta-analysis of three cohort studies of paracetamol exposure in childhood found no increased risk of asthma after adjusting for respiratory infections [24]. The role of paracetamol in childhood asthma and allergic disease remains contentious with different approaches advocated, including primary [25,26] and secondary prevention trials to discover a more reliable measure of the true association [27].…”

Section: Perinatal Exposures Related To Both the Intrauterine Period mentioning

confidence: 99%

Breastfeeding and perinatal exposure, and the risk of asthma and allergies

Lodge

Dharmage

2016

Current Opinion in Allergy &Amp; Clinical Immunology

View full text Add to dashboard Cite

A diverse range of exposures were associated with allergic disease risk, highlighting the susceptibility of children during the perinatal period. Clinicians should reinforce public health messages concerning maternal obesity, smoking, and breastfeeding. The infant gut microbiome is emerging as an important hypothesis, which may mediate the relationship between many perinatal exposures and allergic disease.

show abstract

Acetaminophen and childhood asthma: Pill-popping at our peril?

Cited by 7 publications

References 12 publications

Environmental risk factors for asthma in 13‐14 year old African children

Environmental risk factors for asthma in 13‐14 year old African children

The association between paracetamol use and the risk of asthma, rhinitis and eczema in the Polish population

Breastfeeding and perinatal exposure, and the risk of asthma and allergies

Contact Info

Product

Resources

About