Acetaminophen-induced liver damage in mice: Effects of some medicinal plants on the oxidative defense system

Olaleye, Mary Tolulope; Rocha, João Batista Teixeira da

doi:10.1016/j.etp.2007.10.003

Cited by 176 publications

(89 citation statements)

References 39 publications

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“…One of the characteristic features of oxidative stress is an enhanced lipid peroxidation 20 . The increase of hepatic MDA in the paracetamol group is consistent with previous studies [6][7][8]21 , supporting a role of oxidative stress associated with lipid peroxidation in the development of paracetamol toxicity.…”

Section: Discussionsupporting

confidence: 80%

“…Our study showed that a single dose (2.5 g/kg BW) of paracetamol administration significantly elevated the ALT and AST activity. Leakage of ALT and AST into the blood circulation is a hallmark of hepatic injury in the paracetamol model 7,8,19 . Furthermore, the histopathological changes such as severe centrilobular necrosis, cell swelling, and vacuolar degeneration were observed in the paracetamoltreated group.…”

Section: Discussionmentioning

confidence: 99%

“…Paracetamol overdose causes glutathione depletion and generation of reactive oxygen species resulting in the metabolite covalently binding to hepatic macromolecules 5 . In addition, oxidative stress, including lipid peroxidation can cause irreversible membrane injury and cell death [6][7][8] . Aloe vera, a perennial succulent plant belonging to the Liliaceae family, is widely distributed in tropical areas including Thailand.…”

Section: Introductionmentioning

confidence: 99%

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Negative effects of Aloe vera gel on paracetamol-induced liver injury in rats

Samuhasaneeto¹,

Kajornvuthidej²

2014

ScienceAsia

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The effect of Aloe vera gel on paracetamol induced liver injury in rats was studied using male Wistar rats divided into four groups. Group 1 (control) received 50% sucrose orally twice daily for 2 days. Group 2 (paracetamol) received a single dose (2.5 g/kg BW) of paracetamol dissolved in 50% sucrose. Groups 3 and 4 (A. vera 100 mg and 300 mg, respectively) received a single dose (2.5 g/kg BW) of paracetamol dissolved in 50% sucrose followed by 100 or 300 mg/kg BW of A. vera gel twice daily for 2 days. Blood was collected to determine alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymatic activities. Liver tissue samples were collected for hepatic glutathione, hepatic malondialdehyde (MDA), and histopathology. The results showed that the serum levels of ALT, AST, and hepatic MDA increased significantly in the paracetamol group compared to that of the control group. The liver histopathology in the paracetamol group revealed vacuolization, cell swelling, and mild infiltration of inflammatory cells around the central vein. Necrosis was observed predominantly around the centrilobular and midzonal regions. There were no differences in hepatic glutathione levels between groups and no difference in hepatic MDA levels between the paracetamol group and A. vera gel treated groups. This study concluded that neither 100 nor 300 mg/kg BW of A. vera protected rats from the liver damage induced by a high dose of paracetamol.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Negative effects of Aloe vera gel on paracetamol-induced liver injury in rats

Samuhasaneeto¹,

Kajornvuthidej²

2014

ScienceAsia

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“…flavonoids) to penetrate the lipid membranes constituted with phospholipids ( Gladine ET Al.,2007). In fact, ubiquitous plant polyphenols such as flavonoids, have exhibited a variety of pharmacological activities, including the anti-atherogenesis effect, and their role in prevention of coronary heart disease including atherosclerosis (Harnafi, ET Al.,2007), and have been demonstrated to inhibit lipid peroxidation, and increasing glutathione peroxidase concentrations that have been shown to play a protective role against oxidative damage in various tissues by neutralizing reactive oxygen species ( Wellwood ET Al.,2004& Olaleye ET Al.,2008. Further, several authors have also reported that flavonoids have hypolipidemic and hypocholesteromic effects ( Sharma ET Al., 2008).…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 99%

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

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The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was studied. Three groups of BALB/c mice were treated as following: the first group was fed with normal diet (sugar & water), the second group was fed with high cholesterol (HC) (2% by weight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC diet and given 100 mg/kg rosemary extract (10% w/v) during the last 15 days of treatment period. There was a significant decrease (P < 0.001) in plasma total cholesterol (TC)(-68.57%), low density lipoprotein (LDL) (-56.34%), and triglycerides (TG) (-182.61%). A significant increase in high density lipoprotein (HDL) (38.53%) was obtained in rosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory activity of aqueous extract of R. officinalis was evaluated in BALB/c mice. Mice were treated with three doses of extract (10, 50, 100 mg/kg body weight) for 8 weeks. Humoral immunity against membrane proteins of sheep erythrocytes measured by ELISA showed that IgM (Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78% respectively, in mice fed with 10, 50, and 100 mg/kg of rosemary as compared to the control group (P < 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody titers, in mice fed with rosemary at doses of 10, 50, and 100 mg/kg. Meanwhile, there was no significant different in IgM and IgG responses between 50 and 100 mg/kg (P > 0.05). On the other hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100 mg rosemary extract was significantly higher by 57% than that of cells from the corresponding control animals.

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“…This research interest is related to the traditional uses of bark and fruit extracts throughout Africa as remedies for treating sexually transmitted diseases, dysentery, leprosy, miscellaneous microbial and parasitic infections, skin ulcers, and neoplastic diseases [13,14,16,26]. Moreover, extracts from the plant, as well as isolated compounds, have been found to exert a constellation of other pharmacological effects, including antifungal [24], antiprotozoal (against Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense [23], and several, including multi-drug resistant, strains of Plasmodium falciparum [27][28][29]), antiinflammatory and analgesic [15,19], hepatoprotective [30], anti-fertility [31], CNS-stimulant, antidiarrheal, and antidiabetic [13,14,32], among others.…”

mentioning

confidence: 99%