Acetaminophen-induced nephrotoxicity in rats: Protective role of<i>Cardiospermum halicacabum</i>

Parameshappa, B.; Basha, S.A.; Sen, Saikat; Chakraborty, Raja; Kumar, Gokul Vinod; Sagar, G. Vidya; Sowmya, L.; Raju, K. Kantha; Kumar, Pawan; Lakshmi, Anusha

doi:10.3109/13880209.2011.596843

Cited by 23 publications

(15 citation statements)

References 24 publications

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“…Our results in this study were agree with a previous results suggested all that alterations in sera levels when analysis were taken as an evidence of APAP causing nephreotoxicity in rats models [23,24]. Furthermore, Vigila and Baskaran [25], noticed that, in rats' nephrotoxicity and renal diseases, blood urea and creatinine increased, while proteins and albumin were significantly reduced.…”

Section: Discussionsupporting

confidence: 83%

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

Tayib¹,

Badwi²

2016

IOSR

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Abstract:-The ameliorative effects of Moringa oleifera L. (M. oleifera) is well known to modulate and enhance several immune parameters. The present study investigates the efficacy of the aqueous extract leaves of the M. oleifera on prevention of acetaminophen (APAP) induced acute renal injury in Wistar rats. Thirty albino rats were arranged randomly into 5 groups of 5 rats. Group 2 served as intoxicated group and received APAP (200 mg/kg). Group 3, 4 and 5 received APAP (200 mg/kg) + M. oleifera at doses 250, 500 and 1000 mg/kg, respectively. While first group was served as control rats group. All treatment was given orally to animals for 14 days. Clinical signs were observed regularly and rats were sacrificed and bloods and tissue samples were collected for biochemical and histological analysis. Biochemical results showed that M. oleifera protected the toxic remarks caused by APAP when decrease the elevated levels of serum creatinine, blood urea, cholesterol and lipids, while increases the plasma levels of total protein and albumin. Also, the nephroprotective effects of extracts was strongly correlated with decreased damage of the renal cellular damage, as evidenced by histological findings when compared to the group treated with APAP. Our findings provide evidence to demonstrate that aqueous extract of M. oleifera has a potent nephroprotective effect on APAP-induced kidney injury in rats. It is proposed that the action of plant is through its antioxidative and its ability to restoration or promoting glutathione (GSH) through decrease in the biotransformation of APAP via cytochrome P-450 pathway.

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Section: Discussionsupporting

confidence: 83%

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

Tayib¹,

Badwi²

2016

IOSR

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“…The leaves are used to cure malaria, diarrhea, dysentery and haemorrhoids, asthma, pertusis, oedema, nephritis and oliguria, earaches, ophthalmias and muscular pains [7]. The whole plant possesses various biological activities including anthelmintic, anti-blenorrhagic, antidiarrhoeal, antifertility, anti-inflammatory [8], antipyretic, antiparasitic, analgesic, antibacterial, antioxidant, antiulcer, larvicidal, ovicidal [9], antihyperglycemic and nephroprotective properties [10].…”

Section: Introductionmentioning

confidence: 99%

Foliar Micromorphological Evaluation of Cardiospermum halicacabum L. – An Important Medicinal Climber

Shekhawat¹,

Manokari²

2017

TOPSJ

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“…This was achieved as previously described [21]. Briefly, the animals were fasted overnight for 14 h and a single oral dose of APAP (750 mg/kg body weight (b.w.))…”

Section: Methodsmentioning

confidence: 99%

Membrane Stabilization and Detoxification of Acetaminophen‐Mediated Oxidative Onslaughts in the Kidneys of Wistar Rats by Standardized Fraction of Zea mays L. (Poaceae), Stigma maydis

Sabiu

O’Neill

Ashafa

2016

Evidence-Based Complementary and Alternative Medicine

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This study evaluated membrane stabilization and detoxification potential of ethyl acetate fraction of Zea mays L., Stigma maydis in acetaminophen-induced oxidative onslaughts in the kidneys of Wistar rats. Nephrotoxic rats were orally pre- and posttreated with the fraction and vitamin C for 14 days. Kidney function, antioxidative and histological analyses were thereafter evaluated. The acetaminophen-mediated significant elevations in the serum concentrations of creatinine, urea, uric acid, sodium, potassium, and tissue levels of oxidized glutathione, protein-oxidized products, lipid peroxidized products, and fragmented DNA were dose-dependently assuaged in the fraction-treated animals. The fraction also markedly improved creatinine clearance rate, glutathione, and calcium concentrations as well as activities of superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase in the nephrotoxic rats. These improvements may be attributed to the antioxidative and membrane stabilization activities of the fraction. The observed effects compared favorably with that of vitamin C and are informative of the fraction's ability to prevent progression of renal pathological conditions and preserve kidney functions as evidently supported by the histological analysis. Although the effects were prominently exhibited in the fraction-pretreated groups, the overall data from the present findings suggest that the fraction could prevent or extenuate acetaminophen-mediated oxidative renal damage via fortification of antioxidant defense mechanisms.

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Acetaminophen-induced nephrotoxicity in rats: Protective role ofCardiospermum halicacabum

Cited by 23 publications

References 24 publications

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

Foliar Micromorphological Evaluation of Cardiospermum halicacabum L. – An Important Medicinal Climber

Membrane Stabilization and Detoxification of Acetaminophen‐Mediated Oxidative Onslaughts in the Kidneys of Wistar Rats by Standardized Fraction of Zea mays L. (Poaceae), Stigma maydis

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