Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract

Fotio, Agathe Lambou; Nguepi, Mireille Sylviane Dongmo; Tonfack, Libert Brice; Temdie, Romeo Joel Guemmogne; Nguelefack, Télesphore Benoît

doi:10.1016/j.sajb.2019.08.037

Cited by 18 publications

(10 citation statements)

References 32 publications

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“…Moreover, although liver MDA levels have raised, GPX, SOD, and CAT activities have reduced in mice. Correspondingly, the prior studies' results are consistent with this result (11,12). .…”

Section: Discussionsupporting

confidence: 84%

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Mousavi

Khodayar

Bazle

et al. 2022

Preprint

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Background Acetaminophen (APAP) is known as a safe drug for the relief of fever and pain at therapeutic levels. However, APAP toxicity is considered as the most general cause of acute hepatic damage. This research aimed to evaluate the protective effects of Protocatechuic acid (PCA), as an antioxidant, on the APAP-induced liver toxicity in mice. Methods In this regard, we treated male ICR mice with 40, 80, and 160 mg/kg PCA followed by 300 mg/kg APAP 1 h later for 7 days. By passing 24 h from the APAP administration, they were sacrificed, their Liver was dissected, and blood samples were collected for the evaluation of liver function. Results The results show that APAP-overdose (300mg/kg, IP) could lead to acute liver injury in mice, which is characterized by a rise in serum liver function tests (AST, ALT), pathological changes, and a decline in the antioxidant defense system. In addition, hepatic MDA levels, as the end product of lipid peroxidation, have increased, while the antioxidant enzymes such as GPX, SOD, and CAT activities have decreased in mice. In contrast, it was shown that pre-treatment with PCA could decline MDA, ALT, and AST levels and obviously attenuate the liver histological damage and the antioxidant enzymes. Finally, the results show that PCA had protective effects on the APAP-induced liver damage in mice. Conclusions Our studies show that hepatoprotective natural agents can be effective in APAP -liver toxicity.

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“…Moreover, although liver MDA levels have raised, GPX, SOD, and CAT activities have reduced in mice. Correspondingly, the prior studies' results are consistent with this result (11,12). .…”

Section: Discussionsupporting

confidence: 84%

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Mousavi

Khodayar

Bazle

et al. 2022

Preprint

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“…The anti-oxidant effects of MOLE may be attributed to its contents of phytoconstituents such as polyphenols; flavonoids including quercetin, ellagic acid, kaempferol, and apigenin; and tannins, which scavenge free radicals, inhibit oxidases, and activate the anti-oxidant enzymes (Luqman et al 2012 ). Also, it either increase the biosynthesis of anti-oxidants like GSH or reduce the extent of oxidative stress that leads to less cellular degradation (Fotio et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Moringa oleifera alcoholic extract protected stomach from bisphenol A–induced gastric ulcer in rats via its anti-oxidant and anti-inflammatory activities

Abo-Elsoud

Abdelaziz

Eldaim

et al. 2022

Environ Sci Pollut Res

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This study evaluated the protective potentials of Moringa oleifera leaf alcoholic extract (MOLE) against bisphenol A (BPA)-induced stomach ulceration and inflammation in rats. Control rats received olive oil. Second group administered MOLE (200 mg/kg bwt) by oral gavage. Third group was given BPA (50 mg/ kg bwt) for 4 weeks. Fourth group administrated BPA and MOLE simultaneously. Fifth group was given MOLE for 4 weeks then administered BPA and MOLE for another 4 weeks. Bisphenol A induced gastric ulceration and decreased the volume of gastric juice, prostaglandin E2 (PGE2), reduced glutathione (GSH) and interleukin 10 (IL-10) contents, superoxide dismutase (SOD) activity, and proliferating cell nuclear antigen (PCNA) protein in stomach tissues, while increased the titratable acidity, malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) contents, and caspase-3 and NF‑κB proteins in stomach tissue. However, MOLE ameliorated BPA-induced gastric ulceration and significantly increased the volume of gastric juice, PGE2, GSH and IL-10 contents, SOD activity, and PCNA protein while significantly decreased titratable acidity, MDA, TNF-α and IL-6 contents, and of NF‑κB and caspase-3 proteins in gastric tissue. This study indicated that MOLE protected stomach against BPA-induced gastric injury via its anti-oxidant, anti-apoptotic, and anti-inflammatory activities.

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“…GSH is the antioxidant involved in anti-ROS defense mechanisms [ 32 ]. APAP has been shown to significantly reduce GSH levels in the brains of mice [ 69 ]. Interestingly, GSH levels have been shown to be significantly lower in the cerebellum and Brodmann Area 22 (a portion of Wernicke’s area and thus assists in language comprehension) of individuals with ASD [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder

Furnary

García-Milián

Liew

et al. 2021

Toxics

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Recent epidemiological studies suggest that prenatal exposure to acetaminophen (APAP) is associated with increased risk of Autism Spectrum Disorder (ASD), a neurodevelopmental disorder affecting 1 in 59 children in the US. Maternal and prenatal exposure to pesticides from food and environmental sources have also been implicated to affect fetal neurodevelopment. However, the underlying mechanisms for ASD are so far unknown, likely with complex and multifactorial etiology. The aim of this study was to explore the potential effects of APAP and pesticide exposure on development with regards to the etiology of ASD by highlighting common genes and biological pathways. Genes associated with APAP, pesticides, and ASD through human research were retrieved from molecular and biomedical literature databases. The interaction network of overlapping genetic associations was subjected to network topology analysis and functional annotation of the resulting clusters. These genes were over-represented in pathways and biological processes (FDR p < 0.05) related to apoptosis, metabolism of reactive oxygen species (ROS), and carbohydrate metabolism. Since these three biological processes are frequently implicated in ASD, our findings support the hypothesis that cell death processes and specific metabolic pathways, both of which appear to be targeted by APAP and pesticide exposure, may be involved in the etiology of ASD. This novel exposures-gene-disease database mining might inspire future work on understanding the biological underpinnings of various ASD risk factors.

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Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract

Cited by 18 publications

References 32 publications

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Moringa oleifera alcoholic extract protected stomach from bisphenol A–induced gastric ulcer in rats via its anti-oxidant and anti-inflammatory activities

In Silico Exploration of the Potential Role of Acetaminophen and Pesticides in the Etiology of Autism Spectrum Disorder

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