Acetaminophen: Old drug, new warnings

Schilling, Amy N.; Corey, Rebecca; Leonard, Mandy C.; Eghtesad, Bijan

doi:10.3949/ccjm.77a.09084

Cited by 100 publications

(67 citation statements)

References 14 publications

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“…The US Food and Drug Administration (FDA), concerned about the incidence of acute liver failure due to acetaminophen (Tylenol) overdose, has mandated new labeling on acetaminophen packaging. It has also considered reducing the maximum daily dose from 4 g possibly to 3,250 mg (Schilling et al, 2010).The hepatotoxicity of acetaminophen is due to the induction of the action of promoters in the epidermis. Free radicals cause cell damage through mechanisms of covalent binding and pre-oxidation with subsequent tissue injury.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Jacob

Olaleye

Olugbuyiro

2014

Int J Appl Sci Biotechnol

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Ethnopharmacological relevance: The dry leaf of Alchornea cordifolia (AC) is used, in traditional medicine in the S Nigeria, for the preparation of blood tonic, remedies for urinary, respiratory, liver and gas intestinal disorders. Aim of the study: This study investigated the protective property of AC leaf against liver damage in animals with a view to exploring its use for the treatment of hepatotoxicity in humans. Material and methods: Ethanol extract of A. cordifolia was used to study the hepatoprotective activity in acetaminophen-induced Albino rats (150-200g). Animals in Group 1 served as vehicle control, Group 2 served as hepatotoxin (Acetaminophen 2g/kg treated) group, Groups 3 and 4 served as positive control (Vitamin E and Curcumin 100 mg/kg bw respectively) groups, and Groups 5-8 served as (200-500mg/kg bw) AC leaf extract treated groups while Group 9 served as normal group (AC extract only 300 mg/kg bw). Results: The hepatotoxic group showed hepatocytic necrosis, cellular infiltration and inflammation in the liver. The treatment group restored the liver cells to their normal lobular architecture in a dose dependent manner. The protection offered by the plant extract compared well with the standard antioxidant agents (Curcumin and Vitamin E). Tannins, flavonoids, alkaloids and saponins were detected in the phytochemical screening. Conclusion: Our findings suggest Alchornea cordifolia ethanol leaf extract as promising herpatoprotective herb and give credence to the folkloric use of this plant for the treatment of liver problems.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Jacob

Olaleye

Olugbuyiro

2014

Int J Appl Sci Biotechnol

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“…In children, the recommended dose is 10-15 mg/kg every 4-6 h with a maximum daily dose of 50-75 mg/kg (Schilling et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Acetaminophen hepatotoxicity: an updated review

2014

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“…For children, the recommended dose is 10-15 mg/kg every 4-6 h, with a maximum dose of 50-75 mg per day (Schilling et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

Eugenio‐Pérez

Oca-Solano

Pedraza‐Chaverrí

2016

Pharmaceutical Biology

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Context Acetaminophen (APAP), also known as paracetamol and N-acetyl p-aminophenol, is one of the most frequently used drugs for analgesic and antipyretic purposes on a worldwide basis. It is safe and effective at recommended doses but has the potential for causing hepatotoxicity and acute liver failure (ALF) with overdose. To solve this problem, different strategies have been developed, including the use of compounds isolated from food, which have been studied to characterize their efficacy as natural dietary antioxidants. Objective The objective of this study is to show the beneficial effects of a variety of natural compounds and their use against acetaminophen-induced hepatotoxicity. Methods PubMed database was reviewed to compile data about natural compounds with hepatoprotective effects against APAP toxicity. Results and conclusion As a result, the health-promoting properties of 13 different food-derived compounds with protective effect against APAP-induced hepatotoxicity were described as well as the mechanisms involved in hepatoprotection.ARTICLE HISTORY

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Acetaminophen: Old drug, new warnings

Cited by 100 publications

References 14 publications

Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Hepatoprotective effect of Alchornea cordifolia leaf on liver damage in albino rats

Acetaminophen hepatotoxicity: an updated review

Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity

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