Acetaminophen synthesis and encapsulation using safe mixed-solvents and solution enhanced dispersion by supercritical CO2

Islam, Tariqul; Sarker, Md. Zaidul Islam; Uddin, Abm Helal; Smith, Richard L.

doi:10.1016/j.supflu.2022.105669

Cited by 1 publication

(1 citation statement)

References 31 publications

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“…If the drug does not have good solubility, SC-CO 2 is utilized as an anti-solvent. Supercritical antisolvent (SAS) 7 , gas antisolvent (GAS) 8 – 11 , solution enhanced dispersion by supercritical (SEDS) 12 , 13 , and aerosol solvent extraction system (ASES) 14 , 15 are the techniques used in this scenario. When the supercritical fluid is used as a solute, the gas saturated solution (PGSS) is utilized 16 .…”

Section: Introductionmentioning

confidence: 99%

Solubility measurement of verapamil for the preparation of developed nanomedicines using supercritical fluid

Esfandiari,

Saadati Ardestani,

Alwi

et al. 2023

Sci Rep

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A static method is employed to determine the solubilities of verapamil in supercritical carbon dioxide (SC-CO2) at temperatures between 308 and 338 K and pressures between 12 and 30 MPa. The solubility of verapamil in SC-CO2 expressed as mole fraction are in the range of 3.6 × 10–6 to 7.14 × 10–5. Using four semi-empirical density-based models, the solubility data are correlated: Chrastil, Bartle, Kumar–Johnston (K–J), and Mendez-Santiago and Teja (MST), two equations of state (SRK and PC-SAFT EoS), expanded liquid models (modified Wilson's models), and regular solution model. The obtained results indicated that the regular solution and PC-SAFT models showed the most noteworthy exactness with AARD% of 1.68 and 7.45, respectively. The total heat, vaporization heat, and solvation heat of verapamil are calculated at 39.62, 60.03, and − 20.41 kJ/mol, respectively. Regarding the poor solubility of verapamil in SC-CO2, supercritical anti-solvent methods can be an appropriate choice to produce fine particles of this drug.

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