Acetate absorption and metabolism in the rabbit hindgut.

Marty, J.; Vernay, M.; Abravanel, G.

doi:10.1136/gut.26.6.562

Cited by 29 publications

(8 citation statements)

References 37 publications

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“…Rates of H2/CO 2 acetogenesis ranged from 0.3 to 7.7/tmol acetate per g cecal contents per h, depending on the animal and the method of assay. Since acetate can be absorbed from the rodent cecum and oxidized for energy [8,9], these data taken together with those of Yang et al [8] on the contribution of cecal acetate to rat nutrition, suggest that H2/CO 2 acetogenesis in rat ceca could support up to 0.25% of the animal's maintenance energy requirement. Recently, Lajoie et al [10] confirmed the findings of Prins and Lankhorst by using rat fecal contents, but they also found that rats from their colony were moderately methanogenic.…”

Section: Rodentsmentioning

confidence: 70%

Microbial H2/CO2 acetogenesis in animal guts: nature and nutritional significance

Breznak

1990

FEMS Microbiology Letters

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Section: Rodentsmentioning

confidence: 70%

Microbial H2/CO2 acetogenesis in animal guts: nature and nutritional significance

Breznak

1990

FEMS Microbiology Letters

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“…The problem is that each SCFA is metabolized differently and at several sites in the body (colonic epithelium, liver, peripheral tissue) (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), and the prospects of obtaining blood from the portal vein in volunteers is ethically controversial. An alternative approach is to use an in vitro faecal incubation system, as in the present study.…”

Section: Discussionmentioning

confidence: 99%

Fermentation to Short-Chain Fatty Acids and Lactate in Human Faecal Batch Cultures Intra- and Inter-Individual Variations versus Variations Caused by Changes in Fermented Saccharides

Hove

et al. 1991

Scandinavian Journal of Gastroenterology

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The fermentation to short-chain fatty acids, lactate, and ammonia from several non-starch polysaccharides, glucose, and albumin was investigated in 16.6% faecal homogenates. Increasing concentrations (0-30 mg/ml) of glucose, wheat bran, pectin, ispaghula, cellulose, or albumin incubated for 24 h in homogenates pooled from three individuals increased short-chain fatty acid production linearly. Amounts and ratios of short-chain fatty acids formed were highly dependent on the type of substrate fermented. Fermentable saccharides increased ammonia assimilation, in contrast to the metabolic inert cellulose. Nine faecal homogenates sampled from three individuals at three occasions were incubated for 6 and 24 h. The production of total short-chain fatty acids, acetate, propionate, and butyrate and the accumulation of D- and L-lactate changed considerably in relation to the type of substrate added (cellulose, ispaghula, wheat bran, pectin, gum arabic, and glucose; p less than 10(-4)-10(-7). In contrast, there were no significant (p greater than 0.05) differences in organic acid formation between the nine homogenates, and the intra- and inter-individual variations were of the same magnitude. Variations in fermentation, when measured as organic acid formation, were therefore related to the type of substrate fermented rather than the individual tested.

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“…The VFA appear to provide a regular source of energy for the colonocyte. It is now well established that these bacterial metabolites are partly metabolized in the rabbit colonocyte in the order: butyrate =propionate > acetate; their complete oxidation to carbon dioxide is often the main catabolic pathway Marty et al 1985;. A preferential utilization of butyrate by the large intestine in the human, rat (Roediger, 1980(Roediger, , 1982, guinea-pig ; pig (Rerat et al 1985) has also been suggested.…”

Section: Discussionmentioning

confidence: 99%

Origin and utilization of volatile fatty acids and lactate in the rabbit: influence of the faecal excretion pattern

Vernay¹

1987

Br J Nutr

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1. Interrelations between bacterial metabolites (volatile fatty acids, lactate) in the gut contents and the blood in relation to the faecal excretory cycle (soft or hard faeces) were studied in anaesthetized rabbits.2. It appeared that the level of organic acids in the alimentary tract varied cyclicly with the faecal excretion pattern. The lactate entering the portal circulation originates from the stomach, while the volatile fatty acids (VFA) originate from the hind-gut. Net absorption from the digestive tract and hepatic utilization of fermentation acids were greater when the rabbits produced hard faeces (hard-phase) compared with soft faeces (soft-phase). Propionate and butyrate reaching the liver were almost quantitatively removed; acetate and lactate were available for extra-hepatic tissue metabolism.3. Whatever the excretion pattern the levels of VFA in the arterial circulation remained remarkably constant; blood lactate, however, was lower during the soft-phase.4. Absorption of bacterial metabolites, like their metabolism in the liver, showed a circadian rhythm parallel to the changes in the activity of the adrenal glands, i.e. the activity was enhanced during the hard-phase.

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Acetate absorption and metabolism in the rabbit hindgut.

Cited by 29 publications

References 37 publications

Microbial H2/CO2 acetogenesis in animal guts: nature and nutritional significance

Microbial H2/CO2 acetogenesis in animal guts: nature and nutritional significance

Fermentation to Short-Chain Fatty Acids and Lactate in Human Faecal Batch Cultures Intra- and Inter-Individual Variations versus Variations Caused by Changes in Fermented Saccharides

Origin and utilization of volatile fatty acids and lactate in the rabbit: influence of the faecal excretion pattern

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