Acetazolamide-induced changes of the membrane potentials of the retinal pigment epithelial cell

Kawasaki, Kazuo; Mukoh, S; Yonemura, D; Fujii, Shigeru; Segawa, Yasunori

doi:10.1007/bf00220229

Cited by 24 publications

(11 citation statements)

References 5 publications

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“…This process may be pharmacologically manipulated, as lamotrigine and acetazolamide have both been shown to reduce the amplitude of the EOG light rise. [31][32][33] Additionally, the stimulus for the light rise does not need to be photic, as alcohol (supplied by the choroidal circulation) simulates this phenomenon. 30 In the disease state, the RPE may either not be able to maintain its polar properties due to disorganisation of tight junctions, or may not be able to pump anions efficiently or as normally directed.…”

Section: Discussionmentioning

confidence: 99%

Normal Electrooculography in Best Disease and Autosomal Recessive Bestrophinopathy

Khan

Islam

Holder

et al. 2018

Retina

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SUMMARY STATEMENTThe Bestrophinopathies are a group of inherited eye disorders that arise from either dominant or recessive mutations in the BEST1 gene. Electrooculography is invaluable in the diagnosis of Best disease (BD) and autosomal recessive bestrophinopathy (ARB), as a reduced Arden ratio is a highly penetrant feature of disease. We demonstrate that EOG phenotype in BD and ARB is more variable than currently appreciated. Conclusions:The current work provides significant clinical evidence that the EOG phenotype in BD and ARB is more variable than currently appreciated. As a normal EOG may occur in the presence of a classical fundus appearance, the consequences of BEST1 mutation may be independently expressed, possibly mediated via differential effects on intracellular calcium homeostasis.4

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Section: Discussionmentioning

confidence: 99%

Normal Electrooculography in Best Disease and Autosomal Recessive Bestrophinopathy

Khan

Islam

Holder

et al. 2018

Retina

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“…While the exact mechanism by which acetazolamide decreases CMO remains unclear, several mechanisms of action are proposed. These include regulation of ion transport in the retinal pigment epithelium, 2,11 inhibition of membrane-bound carbonic anhydrase, 12 change in chloride flux and the resting potential of the retinal pigment epithelium, 13 and reduction in subretinal fluid. 14 However, the clinical effectiveness of acetazolamide in reducing CMO of patients with uveitis has been controversial.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of acetazolamide on cystoid macular oedema in patients with Behcet's disease

Lashay

Rahimi

Chams

et al. 2003

Eye

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Aim To study the effect of acetazolamide on cystoid macular oedema (CMO) in patients with Behcet's disease.Patients and methods A total of 67 eyes of 35 Behcet's patients with chronic, but wellcontrolled uveitis, and CMO were randomised into a double-masked, crossover trial comparing the effect of acetazolamide vs placebo. The patients received an initial 4-week course of either 250 mg acetazolamide twice daily (b.i.d.) or placebo, followed by a 4-week washout period. They then received a 4-week course of the reverse study medication. An improvement in visual acuity and fundus fluorescein angiographic findings was assessed.Results In total, 29 patients (55 eyes) completed the trial and were available for analysis. Of the 29, 16 men and 13 were women. The age range was 13-50 years (mean 33.6 years). Patients on acetazolamide showed a slightly better improvement of angiographic signs (at least by one grade improvement) over that of placebo (12 vs five eyes). They also had less deterioration of angiographic signs over that of placebo (three vs seven eyes). However, these findings were not statistically significant (P ¼ 0.99). Acetazolamide had no statistically significant effect (P ¼ 0.53) on the improvement of visual acuity of patients over that of placebo (13 vs eight eyes), nor on the deterioration of visual acuity (three vs 11 eyes).Conclusion Despite seemingly favourable results, the 4-week course of acetazolamide (250 mg b.i.d.) has no statistically significant effect on the improvement of the visual acuity and the fluorescein angiographic findings in Behcet's patients with CMO.

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“…In addition, it is accompanied by an increase in basal membrane resistance [3]. The acetazolamide response also is caused by hyperpolarization of the basal membrane of the RPE, although the drug may need to reach the apical side of the RPE to provoke its effect [4]. The EOG light rise is caused by the depolarization of the basal membrane of the RPE [5].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the nonphotic responses may clarify the nature of RPE disorders because the mechanisms of nonphotic changes in the SP appear to be different from that of the EOG light rise [2][3][4][5]. However, the nonphotic responses have been used only infrequently for clinical evaluations, in part because each test required a separate session to accommodate the long infusion and response time and because of fear of interaction between the drugs.…”

Section: Introductionmentioning

confidence: 99%

Combined photic and nonphotic electro-oculographic responses in the clinical evaluation of the retinal pigment epithelium

et al. 1991

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In an attempt to simplify the recording technique in electrophysiologic evaluation of the retinal pigment epithelium, we combined the electro-oculographic light rise, hyperosmolarity and acetazolamide responses in a single recording session. Recordings were performed in six normal subjects and in seven patients with diabetic retinopathy or retinitis pigmentosa. In the patients with background diabetic retinopathy, the hyperosmolarity responses were slightly reduced, while the acetazolamide response and the light rise was normal. In the patients with proliferative diabetic retinopathy, the hyperosmolarity response and light rise were remarkably reduced, while the acetazolamide response was normal. In the patients with retinitis pigmentosa, the hyperosmolarity response and light rise were decreased, while the acetazolamide response was normal. Despite a small study population, we concluded that the clinical results from our combined recording protocol were essentially the same as those reported for each response separately. Because this recording technique simplifies electrophysiologic evaluation of the retinal pigment epithelium, it may help clarify the mechanisms or localization of retinochoroidal and pigment epithelial diseases.

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Acetazolamide-induced changes of the membrane potentials of the retinal pigment epithelial cell

Cited by 24 publications

References 5 publications

Normal Electrooculography in Best Disease and Autosomal Recessive Bestrophinopathy

Normal Electrooculography in Best Disease and Autosomal Recessive Bestrophinopathy

Evaluation of the effect of acetazolamide on cystoid macular oedema in patients with Behcet's disease

Combined photic and nonphotic electro-oculographic responses in the clinical evaluation of the retinal pigment epithelium

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