Acethylcholinesterase inhibitory potential and antioxidant properties of pyrogallol

Sarıkaya, Sevim Beyza Öztürk

doi:10.3109/14756366.2014.965700

Cited by 57 publications

(32 citation statements)

References 34 publications

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“…The phytochemicals, sitosterol, 1,2,3-benzenetriol (pyrogallol), 3-tert-butyl-4-hydroxyanisole (also known as 3-BHA), syringic acid, oxazolidine-2, 4-dione, 9,12- Octadecadienoic acid and furan-2- carboxylic acid-3-methyl- trimethyl silyl ester identified from the GCMS data (Table 4) have reported antioxidant activities [51–56]. Sitosterol has anti-hepatotoxic activities which normalizes serum transminase and hepatic antioxidant enzymes in hepato-compromised animals [55].…”

Section: Discussionmentioning

confidence: 99%

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Tiwary

Dutta

Dey

et al. 2017

BMC Complement Altern Med

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Background Lagerstroemia speciosa (L.) Pers. has medicinal importance. Bioactive phytochemicals isolated from different parts of L. speciosa, have revealed hypoglycemic, antibacterial, anti-inflammatory, antioxidant and hepato protective properties. Despite one report from Philippines detailing the use of L. speciosa as curative for fever and as well as diuretic, there is no experimental evidence about the hepatoprotective activity of the flower extracts.MethodsSeveral spectroscopic methods, including GC–MS, were used to characterize phytochemicals present in the petal extract of L. speciosa. Ethanol extract of petals was evaluated for anti-oxidant and free radical scavenging properties by using methods related to hydrogen atom transfer, single electron transfer, reducing power, and metal chelation. This study has also revealed the in vitro antioxidant and in vivo hepatoprotective properties of petal extract against carbon tetra chloride (CCl4)-induced liver toxicity in Swiss albino mice. Hepatoprotection in CCl4 -intoxicated mice was studied with the aid of histology and different enzymatic and non-enzymatic markers of liver damage. Cytotoxicity tests were done using murein spleenocytes and cancareous cell lines, MCF7 and HepG2.ResultGCMS of the extract has revealed the presence of several potential antioxidant compounds, of them γ-Sitosterol and 1,2,3-Benzenetriol (Pyrogallol) were the predominant ones. The antioxidants activities of the flower-extract were significantly higher than curcumin (in terms of Nitric oxide scavenging activity; p = 0.0028) or ascorbic acid (in terms of 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay; p = 0.0022). The damage control by the flower extract can be attributed to the reduction in lipid peroxidation and restoration of catalase activity. In vitro cytotoxicity tests have shown that the flower extract did not affect growth and survivability of the cell lines. It left beyond doubt that a flower of L. speciosa is a reservoir of antioxidant and hepatoprotective agents capable of reversing the damage inflicted by CCl4-intoxication.ConclusionResults from the present study may be used in developing a potential hepato-protective health drink enriched with antioxidants from Lagerstroemia speciosa (L.) Pers.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1495-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Tiwary

Dutta

Dey

et al. 2017

BMC Complement Altern Med

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“…Pyrogallol has been reported to possess the ability to scavenge free radicals, antioxidant action, and inhibit the formation of carcinogenic metabolites (20)(21)(22)(23)(24). Pyrogal-lol was also evaluated as a potential inhibitor for acethylcholinesterse enzyme (25).…”

Section: Discussionmentioning

confidence: 99%

Anti-Candida Activities and GC Mass Analysis of Seeds Hydroalcohlic Extract of Rumex obtusifolius

Nazari

Bakhshandeh

Gholami

et al. 2017

Jundishapur J Microbiol

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“…Similarly, Simelane et al [35] estimated the acetylcholinesterase activity of an aqueous extract of Gunnera perpensa rhizome using acetylthiocholine iodide and found the extract to inhibit 23% of AChE activity. Ozturk Sarikaya [68] evaluated the compound pyrogallol 14 as a potential inhibitor for AChE enzyme and the results showed that the compound exhibited potent AChE enzyme inhibitory activity with IC 50 and inhibitory constant ( K i ) values 10.2 and 8.6 μ M, respectively. These findings call for detailed research on acetylcholinesterase (AChE) enzyme inhibition activities of G. perpensa as the mechanisms of action of the species during muscle contraction when used as herbal medicine to induce labour or expel placenta after birth [15, 18, 22, 24–26, 35] are through the inhibition of AChE enzyme.…”

Section: Acetylcholinesterase (Ache) Enzyme Inhibitionmentioning

confidence: 99%

“…The highest activity was obtained from methanol fraction of G. perpensa with EC 50 value of 1.1 μ g/ml against 2,2-di (4-tert-octylphenyl)-1-picrylhydrazyl [72]. Similarly, Ozturk Sarikaya [68] studied different in vitro antioxidant assays such as cupric ion Cu 2+ reducing power, Fe 3+ reducing power, total antioxidant activity by ferric thiocyanate method, ABTS radical scavenging, DMPD radical scavenging, DPPH scavenging, Fe 2+ chelating, O 2 − scavenging, and H 2 O 2 scavenging activities of the compound pyrogallol 14 . The compound pyrogallol 14 inhibited 78.0% lipid peroxidation of linoleic acid emulsion at 30 μ g/mL concentration; and BHA, BHT, α -tocopherol, and trolox exhibited inhibitions of at least 83.8% against peroxidation of linoleic acid emulsion at the same concentration [68].…”

Section: Antioxidantmentioning

confidence: 99%

“…The compound pyrogallol 14 inhibited 78.0% lipid peroxidation of linoleic acid emulsion at 30 μ g/mL concentration; and BHA, BHT, α -tocopherol, and trolox exhibited inhibitions of at least 83.8% against peroxidation of linoleic acid emulsion at the same concentration [68]. In addition to this, pyrogallol 14 was effective of all the scavenging and reducing power results [68]. Previous researchers argued that the antioxidant properties of G. perpensa are probably due to the presence of flavonoids and phenolics [56] as these compounds, for example, flavonoids, are known to have free radical scavenging capacity, coronary heart disease prevention, hepatoprotective, anti-inflammatory, antioxidative, anticancer, and antiviral activities [76].…”

Section: Antioxidantmentioning

confidence: 99%

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From Traditional Usage to Pharmacological Evidence: Systematic Review of Gunnera perpensa L.

Maroyi

2016

Evidence-Based Complementary and Alternative Medicine

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Gunnera perpensa is the only species of the genus Gunnera that has been recorded in Africa. Its leaves, rhizomes, roots, and stems are reported to possess diverse medicinal properties and used to treat or manage various human and animal diseases and ailments. Gunnera perpensa is an ingredient in many herbal concoctions and prescriptions which have been used to induce or augment labour, postnatal medication, to treat parasitic diseases, urinary complaints, kidney problems, general body pains, sexually transmitted infections, and many other diseases. Several classes of phytochemicals including alkaloids, benzoquinones, ellagic acids, flavonoids, phenols, proanthocyanidins, tannins, and minerals have been isolated from G. perpensa. Scientific studies on G. perpensa indicate that it has a wide range of pharmacological activities including acetylcholinesterase, anthelmintic, antibacterial, antifungal, antinociceptive, anti-inflammatory, antioxidant, antitumour, lactogenic, and uterotonic. Gunnera perpensa has a lot of potential as a possible source of pharmaceutical products for the treatment of a wide range of both human and animal diseases and ailments. Some of the chemical compounds isolated from G. perpensa have demonstrated various biological activities when investigated in in vitro assays. Future research should focus on the mechanisms of action of the isolated compounds, their efficacy, toxicity, and clinical relevance.

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Acethylcholinesterase inhibitory potential and antioxidant properties of pyrogallol

Cited by 57 publications

References 34 publications

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Radical Scavenging Activities of Lagerstroemia speciosa (L.) Pers. Petal Extracts and its hepato-protection in CCl4-intoxicated mice

Anti-Candida Activities and GC Mass Analysis of Seeds Hydroalcohlic Extract of Rumex obtusifolius

From Traditional Usage to Pharmacological Evidence: Systematic Review of Gunnera perpensa L.

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