Acetic formic anhydride a review

Green chemistry multicomponent protocol for formylation and Knoevenagel condensation for synthesis of (Z)-5-arylaminomethylene pyrimidine 2, 4, 6-trione derivatives in water

“…Electrospray ionization mass spectrometry (ESIMS): m/z 277.91 (M + 2) (8). All synthesized new derivatives B (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) showed the strong absorption bands (λ max) in the range of 279.76-374.6 nm owing to the π-π* transition as well as presence of exocyclic CH of the barbituric acid in their UV spectra.…”

“…Alternative solvents suitable for green chemistry are those that have low toxicity, inert, easy to degrade, and environmental friendly. Alternative media to organic solvents include water (4), ionic liquids (5), supercritical solvents (6), hydrotropic solutions (7), and so on. Using this reaction protocol, we have obtained 5-arylaminomethylene pyrimidine 2, 4, 6-trione derivatives in very good to moderate yields without using catalysts or organic solvent.…”

Inhibition of Invasion and Capillary-like Tube Formation by Retrohydroxamate-based MMP Inhibitors

“…20 Hydrolysis of the β-lactam furnished acid 8, which was subsequently coupled by standard peptide coupling conditions using L-amino acid-N-methylamide to give 9 with a good yield. Hydroxylamine 9 was N-formylated using acetic anhydride/formic acid 21 and subsequent removal of the O-benzyl protecting group by Pd-catalyzed hydrogenation provided the target compound 2. MMP Inhibitory Activity.…”

Synthesis of N-Formylation of Amines using Various Ion Exchanged Forms of Zeolite-A as Catalysts

“…The main application of Formamides is to use in the synthesis of Formamidines [7] and in peptide synthesis acts as useful amino protecting group [8]. Various methods have been previously reported in literature for the synthesis of N-Formylation of amines and various catalysts were used for this reaction, such as acetic formic anhydride [9], activated formic acid using Dicyclohexylcarbodiimide [10] or,1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide [11], chloral [12], activated formic esters [13], ammonium formate [14], 2,2,2-trifluoroethyl formate [15], ZnO [16], PEG-400 [17], Formic acid-ZnCl 2 [18], polyvinyl alcohol [19], Na + -montmorillonite [20], Nano Cerium Oxide [21], Natrolite zeolite [22], HCOOH Sodium formate [17], Silica-bonded N-Propyl Sulfamic acid [23], TiCl 3 (OTF) [24], CDMT [25], KF-AL 2 O 3 [26], Formic acid in Toluene [18], Formic acid in polyethylene glycol [17], Natural HEU Zeolite [27] . However above listed methods have some limitations such as long reaction time, formation of undesirable byproducts, hygroscopicity expensive reagents, and thermal instability of the reagents, and high temperature for reaction completion.…”