Acetone chemical ionization mass spectrometry

Prabhakar, S.; Vairamani, M.

doi:10.1002/(sici)1098-2787(1997)16:5<259::aid-mas2>3.0.co;2-g

Cited by 13 publications

(1 citation statement)

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“…Several automated chromatography separation systems have been developed to reduce the personnel workload. − In fact, automated methods have long been successfully established and adopted in fields of traditional stable isotope analysis. − In recent years, the development and adoption of similar methods for radiogenic and non-traditional stable isotopes have also been developed, − where the eluent is controlled by a peristaltic pump or syringe pump. Among these pump-based systems, the commercialized fully automated ion exchange chromatography system prepFAST-MC (ESI, Omaha, NE, USA) has received increasing interest.…”

Section: Introductionmentioning

confidence: 99%

Development of an Automatic Column Chromatography Separation Device for Metal Isotope Analysis Based on Droplet Counting

Zhou

Miao

et al. 2021

Anal. Chem.

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A novel, simple, cost-effective, reliable, and practical automatic column chromatography separation device capable of simultaneously purifying samples for radiogenic and non-traditional stable isotope analysis has been developed. The device avoids the use of any pump and features eluent driving by the siphon effect (gravity) and quantitative control by infrared droplet counting. Several factors affecting the control of droplets were investigated, including types and concentrations of eluents and the height of the liquid level. Results showed that accurate dripping of the eluent could be readily achieved by controlling the number of droplets under selected conditions. The separation performance of the device was first demonstrated by the elution of Sr and Cd in synthetic matrix solutions. The recoveries of Sr and Cd samples were better than 87.6 and 95.0%, respectively, and the whole procedure blank was about 0.3 ng for Sr and 0.1 ng for Cd. Finally, the reliability of the device was further validated by the purification of Sr and Cd from different geological reference materials (NIST 2711a, Nod-A-1, BCR-2, and BHVO-2). The determined Cd and Sr isotope values agree well with their reference values within the uncertainty range. All these results clearly demonstrate the reliability and practicability of the proposed device, which provides a promising method for the automated purification of isotope samples.

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Section: Introductionmentioning

confidence: 99%

Development of an Automatic Column Chromatography Separation Device for Metal Isotope Analysis Based on Droplet Counting

Zhou

Miao

et al. 2021

Anal. Chem.

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Chemical Ionization Mass Spectrometry: Theory and Applications

Munson

2000

Encyclopedia of Analytical Chemistry

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Chemical ionization mass spectrometry (CIMS) is a technique for forming ions of the compound of interest (analyte, A) by ion/molecule reactions from reactant ions of a reagent gas that is generally present in a much greater abundance than the analyte. The reactant ions are generally produced by electron ionization (EI) of the reagent gas. The ions produced by EI often react with the large excess of the reagent gas to form the actual reagent ions that react with the analyte. CIMS is performed with both positively and negatively charged reactant ions. The most common ion/molecule reactions in CIMS are proton transfer (which forms AH + or [ A − H ] − ions), hydride transfer (which forms [ A − H ] + ions), charge or electron transfer (which forms A +• or A −• ions), and adduct formation or attachment (which forms [A + R] + or [A + R] − ions). Fragment ions from decompositions of these AH + , A ±• , [A − H] ± , and [A + R] ± ions are frequently observed. The extent of fragmentation can be controlled by the choice of reagent gas used and can be predicted to some extent from ionic thermochemical data. Collisionally stabilized electron capture at high pressures (to form A −• ions) is often classified as chemical ionization (CI). The most common use of CIMS in analytical mass spectrometry is to obtain simplified mass spectra of compounds, often one species spectra, which can be used for quantitative analysis of mixtures. CIMS can be performed with any type of mass spectrometer (quadrupole, magnetic, time‐of‐flight (TOF), Fourier transform ion cyclotron resonance (FTICR), ion trap) and CIMS capabilities are routinely available on many commercial instruments. With ion trap or FTICR mass spectrometers, it is possible to select specific reactant ions. It is generally considered that CI and EI sensitivities are approximately the same in the positive ion mode and that electron capture CI at high pressures for compounds with high electronegativities gives a much greater sensitivity than other EI or CI techniques. CIMS has the same general limitations as electron ionization mass spectrometry (EIMS) on the volatility and thermal stability of the compound being analyzed. However, direct insertion of the sample into the source of the mass spectrometer allows the analysis of relatively involatile and thermally unstable compounds.

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