Acetone fraction from Sechium edule (Jacq.) S.w. edible roots exhibits anti-endothelial dysfunction activity

Trejo-Moreno, Celeste; Castro-Martínez, Gabriela; Méndez-Martínez, Marisol; Jiménez-Ferrer, Enrique; Pedraza‐Chaverrí, José; Arrellín, Gerardo; Zamilpa, Alejandro; Medina-Campos, Omar Noel; Lombardo-Earl, Galia; Barrita-Cruz, Gerardo Joel; Hernández, Beatríz; Ramírez, Christian Carlos; Santana, María Angélica; Fragoso, Gladis; Rosas, Gabriela

doi:10.1016/j.jep.2018.02.036

Cited by 13 publications

(11 citation statements)

References 59 publications

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“…However, the root had not been studied as a therapeutic tool in hepatic diseases. In a previous work by our research group, an acetone fraction of S. edule root (rSe-FA) was found to be effective in controlling ED induced in mice by chronic administration of a sub-effective dose of ANGII; in that study, ANGII was found to induce morphological changes in the liver similar to those of NASH (Trejo-Moreno et al, 2021), and that administration of this fraction prevented such damage (Trejo-Moreno et al, 2018). Moreover, the fraction was rich in cinnamic and coumaric acids, whose antioxidant (Shen et al, 2019;Anlar, 2020) and anti-inflammatory properties (Karatas et al, 2020)…”

Section: Introductionmentioning

confidence: 89%

“…The remaining three groups were treated with ANGII (Sigma, St. Louis, MO, United States) i. p, 0.01 μg/kg/day (ANGII) (Trejo-Moreno et al, 2021), for 11 weeks, either alone or coadministered p. o. with Losartan (LOS) (Cozaar ® , Merck Sharp & Dohme, Kenilworth, NJ, United States) at a dose of 10 mg/kg diluted in 0.2% carboxymethylcellulose (CMC, Maquimex, Mexico) (Bastaki, et al, 2018) or rSe-HA diluted in water, at a dose of 11 mg/kg, for 11 weeks. Both treatment time and the dose administered were based on data previously reported by Trejo-Moreno et al (2018). Dose calculation was based on the concentration of cinnamic acid in the HA extract, which in turn was calculated based on the concentration of the same molecule in the acetone extract used by Trejo-Moreno et al (2018).…”

Section: Animals and Experimental Groupsmentioning

confidence: 99%

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Hepatoprotective effect of hydroalcoholic extract from root of Sechium edule (Jacq.) Sw. over hepatic injury induced by chronic application of angiotensin II

et al. 2022

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Liver damage is characterized by lipid accumulation in the liver, a prooxidant/proinflammatory state, necrosis, and fibrosis. Given the multifactorial conditions and complexity of the disease and the contribution of oxidative stress and inflammation in its development, phytomedicine is a good option for its control. Liver damage was induced in male C57BL/6J mice by chronic administration of angiotensin II (ANGII) (0.01 μg/kg/day, administered daily intraperitoneally). A hydroalcoholic extract of Sechium edule root (rSe-HA), standardized for its cinnamic acid content, was used to control the incidence of liver damage in mice (11 mg/kg/day of rSe-HA, administered orally). After 11 weeks, the mice were sacrificed and adipose tissue, serum, and liver were obtained. Hepatic cytokine and triglyceride (TG) concentrations were determined, and any histopathological changes were recorded. Meanwhile, ANGII treatment increased serum TG concentration (62.8%), alanine aminotransaminase (GPT/ALT) levels (206%), as well as TG accumulation (82.7%), hepatomegaly (32.1%), inflammation (measured by TNFα (70%), IL-1β (103%), IL-6 (92%), and TGFβ (203%) levels, along with inflammatory cell recruitment), and fibrosis with respect to untreated controls. rSe-HA prevented these increases, maintaining all parameters evaluated at values similar to those of the control group. Overall, our results support the hepatoprotective effects of rSe-HA against NAFLD and NASH, which are often the gateway to more severe pathologies.

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Section: Introductionmentioning

confidence: 89%

Section: Animals and Experimental Groupsmentioning

confidence: 99%

Hepatoprotective effect of hydroalcoholic extract from root of Sechium edule (Jacq.) Sw. over hepatic injury induced by chronic application of angiotensin II

et al. 2022

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“…This plant has been used for the treatment of renal disease, obesity, and arteriosclerosis [1]. There are several documents that reported about chayote phytochemical investigation [1][2][3][4][5]. There are various groups of secondary metabolites were produced, including fatty acid derivatives [2], flavonoids [1,3,4], and organic acids [5].…”

Section: Introductionmentioning

confidence: 99%

“…There are several documents that reported about chayote phytochemical investigation [1][2][3][4][5]. There are various groups of secondary metabolites were produced, including fatty acid derivatives [2], flavonoids [1,3,4], and organic acids [5]. Furthermore, these compounds exhibited pharmaceutical activities such as anti-endothelial dysfunction activity [5] and lipid accumulation inhibition [4].…”

Section: Introductionmentioning

confidence: 99%

“…There are various groups of secondary metabolites were produced, including fatty acid derivatives [2], flavonoids [1,3,4], and organic acids [5]. Furthermore, these compounds exhibited pharmaceutical activities such as anti-endothelial dysfunction activity [5] and lipid accumulation inhibition [4]. In addition, Brassica oleracea var gongylodes L. is a member of the Brassicaceae family which is a source of nutrients such as dietary fiber, folic acid, calcium, and vitamins [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Encapsulation Wall Materials and Drying Method on Physicochemical Properties and Digestibility of Encapsulated Chayote (<em>Sechium edule</em> (Jacq.) Swartz) and Kohlrabi (<em>Brassica oleracea var gongylodes</em> L.) Extracts

Ploypetchara

Sorndech

Auranwiwat

et al. 2021

Food Science and Engineering

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Chayote (Sechium edule (Jacq.) Swartz) and kohlrabi (Brassica oleracea var gongylodes L.) are medicinal plants widely distributed in Thailand. Several traditional medicines usually contain these extracts due to their pharmaceutical activities. However, appropriate technologies that are used for protection, stabilization, and slow release of plant extracts are a lot desired in terms of food application. In this study, chayote and kohlrabi extracts were encapsulated by several kinds of wall materials (maltodextrin, and the combination of maltodextrin and gum arabic or alginate) and drying methods (freeze-drying and tray-drying techniques). Thus, the objective of this research was to determine morphological and physicochemical properties, wall materials releasing, and antioxidant activity of encapsulated chayote and kohlrabi extracts powder. The morphology of all encapsulated chayote and kohlrabi extracts powder showed irregular spherical shape, monodispersity, and smooth surface. The encapsulated chayote and kohlrabi extracts powder with tray-drying technique tend to have more darkness and redness in color than the freeze-drying technique. Wall material releasing was expressed in glucose liberation of encapsulated extracts powder after amylolytic enzyme digestion. Encapsulation using maltodextrin as wall material provided higher wall material releasing than the other samples. After digestion analysis, the digested residues were examined for antioxidant activity. The results showed that the combination of maltodextrin and alginate for both freeze-drying and tray-drying techniques provided higher antioxidant activity after 60 and 120 min of digestion. Thus, the combination of maltodextrin and alginate, and drying with the freeze-drying technique was the best treatment in this experiment. This data can lead to a better understanding of wall materials types and releasing characteristics, which are used to control bioactive compounds liberation in the gastrointestinal tract.

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Chemistry and Biology of Selected Mexican Medicinal Plants

Mata

Figueroa

Navarrete

et al. 2019

Progress in the Chemistry of Organic Natural Products

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Acetone fraction from Sechium edule (Jacq.) S.w. edible roots exhibits anti-endothelial dysfunction activity

Cited by 13 publications

References 59 publications

Hepatoprotective effect of hydroalcoholic extract from root of Sechium edule (Jacq.) Sw. over hepatic injury induced by chronic application of angiotensin II

Hepatoprotective effect of hydroalcoholic extract from root of Sechium edule (Jacq.) Sw. over hepatic injury induced by chronic application of angiotensin II

Impact of Encapsulation Wall Materials and Drying Method on Physicochemical Properties and Digestibility of Encapsulated Chayote (<em>Sechium edule</em> (Jacq.) Swartz) and Kohlrabi (<em>Brassica oleracea var gongylodes</em> L.) Extracts

Chemistry and Biology of Selected Mexican Medicinal Plants

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