2024
DOI: 10.1021/acs.oprd.4c00188
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Acetonitrile Regeneration from Oligonucleotide Production Waste Streams

Ruairí Ó Meadhra,
Christian Fleury,
Bertrand Guelat
et al.

Abstract: A distillation concept is described to process organic and aqueous waste streams from an oligonucleotide process to regenerate 85% of acetonitrile contained in the wastes, for reintroduction back into the oligonucleotide process. Careful selection of the streams to send to regeneration based on their acetonitrile content was shown to simplify the number of processing steps and minimize the size of the equipment required for regeneration. Availability of accurate vapor−liquid equilibrium data was shown to be ke… Show more

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