Acetyl-keto-β-boswellic acid induces lipolysis in mature adipocytes

Liu, Jing; Toy, Wan Ching; Liu, Sylvia; Cheng, Anton; Lim, Boon Khim; Subramaniam, Tavin; Sum, Chee Fang; Lim, Su Chi

doi:10.1016/j.bbrc.2012.12.136

Cited by 24 publications

(17 citation statements)

References 17 publications

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“…The antioxidant capacity of natural products is generally associated with the content of polyphenolic compounds in their composition (35). Among other constituents, BS oleo-gum resin is rich in pentacyclic terpenoids that exhibited anti-inflammatory effects by targeting multiple pathways in a range of disorders, including rheumatoid arthritis, ulcerative colitis, bronchial asthma, osteoarthritis and cancer (12). AKBA and boswellic acids have been previously reported to inhibit the activation of NF-κB and production of TNF-α, IL-1, -2, -4 and -6 (7).…”

Section: Discussionmentioning

confidence: 99%

“…These anti-inflammatory properties has been attributed to the boswellic acids (α, β and γ-boswellic acid), acetyl-β boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid (10), which can also simultaneously reduce oxidative stress (11). This group of triterpenic acids have also been reported to exhibit anti-cancer properties, controlling cell proliferation, metastasis, invasion and migration by targeting cell signaling components, including MAPK, NF-κB, TNF-α and ERK1/2 (12,13).…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, anti‑inflammatory and anti‑fibrotic effects of Boswellia serrate gum resin in CCl4‑induced hepatotoxicity

et al. 2019

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The present study aims to investigate the potential antioxidant, anti-inflammatory and anti-fibrotic effects of Boswellia serrate (BS) gum resin against carbon tetrachloride (CCl 4 )-induced liver damage. Four groups consisting of eight rats each were designated: Group I, normal healthy control; group II, CCl 4 -induced liver fibrosis; group III, CCl 4 -induced liver fibrosis followed by BS treatment daily for two weeks; and group IV, CCl 4 -induced liver fibrosis followed by silymarin treatment daily for two weeks. Expression of tumor necrosis factor-α (TNF-α) and nuclear factor κB (NF-κB), interleukin-6 (IL-6), transforming growth factor-β (TGF-β) and cyclooxygenase-2 (COX-2) were assessed, in addition to histopathological and fibrotic changes in liver tissues isolated from the rats. BS significantly ameliorated CCl 4 -induced increases in serum aspartate (AST) and alanine transaminase (ALT) levels, reduced lactate dehydrogenase (LDH) activities in addition to restoring total bilirubin, triglyceride and albumin levels. BS treatment also alleviated oxidative stress and improved total antioxidant capacity in the liver, and reduced the expression of TNF-α, NF-κB, TGF-β, IL-6 and COX-2. On a histopathological level, BS treatment also exhibited antifibrotic activity. In conclusion, these findings suggest that BS contains potentially hepatoprotective effects against CCl 4-induced liver injury via its antioxidant, anti-inflammatory and antifibrotic characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant, anti‑inflammatory and anti‑fibrotic effects of Boswellia serrate gum resin in CCl4‑induced hepatotoxicity

et al. 2019

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“…Moreover, there was an increase in the AMPK level through the inhibition of the liver kinase B1, suggesting a potential anti‐obesity effect of UA . Although numerous evidence has shown the role of UA on anti‐obesity effects and comorbidities , beneficial effects have also been described for various diseases, such as the inhibition of tumour growth , sepsis attenuation , ageing , human immunodeficiency virus , inflammation and rheumatoid arthritis . Table systematically describes the studies that used UA in the modulation of adiposity in both rodents and humans.…”

Section: Discussionmentioning

confidence: 99%

Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review

et al. 2017

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This systematic review aimed at addressing the ursolic acid actions as an adjunctive treatment of the obesity-mediated metabolic abnormalities. To explore our aims, we used the literature search including clinical and animal studies using the Medline and Google Scholar (up to December 2015). Out of 63 screened studies, 17 presented eligibility criteria, such as the use of ursolic acid on adiposity, energy expenditure and skeletal muscle mass in mice and humans. In the literature, we found that several physiological and molecular mechanisms are implicated in the effects of ursolic acid on obesity, energy expenditure, hepatic steatosis, skeletal muscle mass loss and physical fitness, such as (1) increase of thermogenesis by modulation adipocyte transcription factors, activation of 5' adenosine monophosphate-activated protein kinase and overexpression of the uncoupling protein 1 thermogenic marker; (2) enhancement of skeletal muscle mass by activation in bloodstream growth hormone and insulin-like growth factor-1 concentrations secretion, as well as in the activation of mammalian target of rapamycin and inhibition of ring-finger protein-1; and (3) improvement of physical fitness by skeletal muscle proliferator-activated receptor gamma co-activator alpha and sirtuin 1 expression. Therefore, supplementation with ursolic acid may be an adjunctive therapy for prevention and treatment of obesity-mediated and muscle mass-mediated metabolic consequences.

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“…ities [12] of some triterpenes from various plants have been reported. Antiobesity properties of some other triterpenoid compounds such as ursolic acid and acetyl-keto-β-boswellic acid have also recently been documented [3,13]. The diverse pharmacological effects possessed by plant-derived triterpenes have made these compounds new targets for drug development against an array of life-threatening diseases.…”

mentioning

confidence: 99%

“…Inhibition of lipid digestive enzymes and, therefore, limiting intestinal absorption of dietary lipids, as well as inhibition of adipogenesis and lipolysis could be an ideal therapeutic approach to reduce incidences of hyperlipidemia and its related diseases [17,18]. The literature lists some plant-derived triterpenes such as ursolic acid, oleanolic acid, and acetyl-keto-β-boswellic acid as having antiobesity properties [3,13,19]. The two lanosteryl triterpenes isolated from the stem bark of P. longifolia effectively inhibited the activities of pancreatic lipase, cholesterol esterase, and HSL with IC 50 values ranging from 0.04 to 0.31 mg/mL (l " Table 2).…”

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confidence: 99%

In Vitro Antihyperlipidemic Potential of Triterpenes from Stem Bark of Protorhus longifolia

et al. 2014

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Two lanostane triterpenes, 3β-hydroxylanosta-9,24-dien-21-oic acid (1) and methyl-3β-hydroxylanosta-9,24-dien-21-oate (2), were isolated from the stem bark of Protorhus longifolia. Their structures were deduced on the basis of spectroscopic analysis (NMR, HRMS, IR). This study investigated the in vitro anti-adipogenic activity of the two triterpenes. Their inhibitory activity was evaluated on selected lipid digestive enzymes (pancreatic lipase and cholesterol esterase). The inhibitory activity of the compounds on hormone-sensitive lipase and their ability to bind bile acids were also evaluated. The effect of the compounds on glucose uptake in C2C12 muscle cells and 3T3-L1 adipocytes, and on triglyceride accumulation in 3T3-L1 adipocytes was investigated. The triterpenes effectively inhibited the activities of the enzymes with IC50 values ranging from 0.04 to 0.31 mg/mL. The compounds showed a high affinity for secondary bile acids. Both compounds stimulated glucose uptake in C2C12 muscle cells and 3T3-L1 adipocytes. Compound 1 significantly reduced triglyceride accumulation in mature differentiated 3T3-L1 adipocytes. It is apparent that these lanostane triterpenes enhance glucose uptake and suppress adipogenesis, which together with their inhibitory effects on lipid digestive enzymes suggests that they have antihyperlipidemic potential.

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Acetyl-keto-β-boswellic acid induces lipolysis in mature adipocytes

Cited by 24 publications

References 17 publications

Antioxidant, anti‑inflammatory and anti‑fibrotic effects of Boswellia serrate gum resin in CCl4‑induced hepatotoxicity

Antioxidant, anti‑inflammatory and anti‑fibrotic effects of Boswellia serrate gum resin in CCl4‑induced hepatotoxicity

Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review

In Vitro Antihyperlipidemic Potential of Triterpenes from Stem Bark of Protorhus longifolia

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