Acetyl-L-Carnitine Alleviates Valproate-Induced Autistic-Like Behaviors Through Attenuation of Hippocampal Mitochondrial Dysregulation

Zahedi, Elham; Sadr, Seyed Shahabeddin; Sanaeierad, Ashkan; Roghani, Mehrdad

doi:10.2139/ssrn.4249935

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the same time, mice in the VPA and the control groups were daily administered with normal saline via intragastric administration in an equivalent dose format. Following the protocol established by Zahedi et al, on embryonic day 12.5, pregnant mice in the VPA and AGM intervention groups received an intraperitoneal injection of 600 mg/kg VPA (Guimaraes-Souza et al, 2019;Zahedi et al, 2023). The pregnant mice in the control group received equal amounts of normal saline daily during pregnancy.…”

Section: Animal Experimental Protocolmentioning

confidence: 99%

The prenatal use of agmatine prevents social behavior deficits in VPA‐exposed mice by activating the ERK/CREB/BDNF signaling pathway

Chen,

Xu,

Zhao

et al. 2024

Birth Defects Research

View full text Add to dashboard Cite

BackgroundAccording to reports, prenatal exposure to valproic acid can induce autism spectrum disorder (ASD)‐like symptoms in both humans and rodents. However, the exact cause and therapeutic method of ASD is not fully understood. Agmatine (AGM) is known for its neuroprotective effects, and this study aims to explore whether giving agmatine hydrochloride before birth can prevent autism‐like behaviors in mouse offspring exposed prenatally to valproic acid.MethodsIn this study, we investigated the effects of AGM prenatally on valproate (VPA)‐exposed mice. We established a mouse model of ASD by prenatally administering VPA. From birth to weaning, we evaluated mouse behavior using the marble burying test, open‐field test, and three‐chamber social interaction test on male offspring.ResultsThe results showed prenatal use of AGM relieved anxiety and hyperactivity behaviors as well as ameliorated sociability of VPA‐exposed mice in the marble burying test, open‐field test, and three‐chamber social interaction test, and this protective effect might be attributed to the activation of the ERK/CREB/BDNF signaling pathway.ConclusionTherefore, AGM can effectively reduce the likelihood of offspring developing autism to a certain extent when exposed to VPA during pregnancy, serving as a potential therapeutic drug.

show abstract

Section: Animal Experimental Protocolmentioning

confidence: 99%