Acetyl-l-carnitine enhances myelination of regenerated fibers of the lateral olfactory tract

Abstract

It is well known that acetyl-l-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases. In addition, it has been reported that ALC facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, consistently occurred in newborn rats and a majority of these regenerated fibers were unmyelinated in neonatally LOT-transected young adult rats. To investigate the effects of ALC treatment on myelination in LOT, neonatal rats were treated with ALC after LOT transection. Immunohistochemistry for myelin basic protein showed more positive areas in ALC-treated rats than in control rats. Moreover, the number of myelinated axons of regenerated fibers was assessed using electron microscopy and was found to be statistically higher in ALC-treated rats compared to control rats. The study revealed that ALC accelerates myelination of regenerated fibers in neonatally LOT-injured young adult rats.

Convergence of Plasma Metabolomics and Proteomics Analysis to Discover Signatures of High-Grade Serous Ovarian Cancer

“…Three proteins, phosphopantothenate-cysteine ligase (PPCS), myelin P2 protein (PMP2), and tubulin beta chain (TUBB), were significantly correlated with L-carnitine (AC.0.0) and PC-O (30:0). The carnitine system is related to cancer metabolic plasticity [71] and acetylation of carnitine facilitates myelination of regenerated axons after peripheral nerve injuries with physical binding to PMP2 and TUBB [72]. In order to validate prognostic protein marker candidates, survival analysis was performed on the webpage Kaplan-Meier plotter (KM plotter, http://kmplot.com/) with mRNA expression and a progression-free survival (PFS) period [73] for 1232 serous ovarian cancer patients.…”