Acetyl strophanthidin used as a measure to evaluate the status of digitalization

Plasma Concentration and Urinary Excretion Kinetics of Acetyl Strophanthidin

“…39' 40 The onset of pharmacologic effects after AS administration has also been noted to be more rapid than for the cardiac glycosides, including ouabain. For example, the time interval from intravenous injection to peak slowing of the ventricular response among patients with atrial fibrillation has been noted to be [15][16][17][18][19][20] hours41 also agree well with the respective plasma concentration half-lives. Acetyl strophanthidin plasma concentration and urinary excretion halflives noted in the present study tended to be somewhat greater than previously determined halftimes for dissipation of pharmacologic effects.…”

“…3 5, 23-26 Toxic arrhythmias typically persist for 5-30 min. [15][16][17][18]21 Slowing of the ventricular response in patients with atrial fibrillation has been shown to persist for 6-8 hours after single doses of AS,25 ' 26 dissipating with a half-life of about 80 min. The half-life of dissipation of left ventricular ejection time shortening after AS administration in patients with normal hemodynamics has been estimated at 40 min.27 Dissipation of the (dp/dt) /P increase in closed-chest dogs after AS occurred with a half-life of 17 min.5 Thus, this agent is by far the most rapidly acting digitalis analog which has received extensive clinical and experimental use.…”

Diagnostic de l’intoxication digitalique et son traitement

“…Le produit n'existe pas encore en Suisse. Ce test, prôné par plusieurs auteurs [15,16], rend de grands services à condition d'être méti culeusement appliqué : injecter 0,1 mg i.v. loutes les 5 à 10 mi nutes, sous contrôle électrocardiographique (dose totale 1,2 mg) et noter l'apparition tant des symptômes que des signes électriques de l'intoxication digitalique.…”