Acetylaniline modified hypercrosslinked polystyrene resins and their equilibria and kinetics towards glabridin from Glycyrrhiza glabra L. extracts

Li, Xiaoting; Liu, Yi; Liu, Yongfeng; Di, Duolong

doi:10.1016/j.colsurfa.2016.09.067

Cited by 3 publications

(1 citation statement)

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“…This by no means complete list of analytes convincingly demonstrates the universality of hydrophobic HP sorbents. Here, we would like to note that the widespread idea to enhance the adsorption ability of HP polymers toward polar compounds by introducing polar groups into HP structure [6][7][8][9][10][11][12][13][14][15] does not seem to be essential. Indeed, the adsorption properties of HP sorbent Isolute ENV+ (Biotage, Sweden), now presented as strongly hydroxylated one, do not differ noticeably from the adsorption ability of the other really hydrophobic hyper-cross-linked sorbents [4].…”

Section: Introductionmentioning

confidence: 99%

Trace enrichment of phenylcarboxylic acids from a model biological fluid and serum of human blood

Popov

Blinnikova

Tsyurupa

et al. 2019

J of Separation Science

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The study was focused on the development of a solid‐phase extraction protocol for seven phenylcarboxylic acids from albumin solutions by using unmodified hyper‐cross‐linked polystyrene restricted access materials with crosslinking degrees varying from 100 to 400% (four of the acids are known to be markers of sepsis). The breakthrough volume of the most hydrophilic 3,4‐dihydroxybenzoic acid rises as the sorbent bridging extent grows. Inversely, the breakthrough volume of the most hydrophobic 3‐phenylpropionic acid was found to decrease considerably when the degree of crosslinking exceeds 200%. This unusual pattern is because of the superposition of two opposite tendencies. Increasing substitution extent of phenyls facilitates their π‐π‐interactions with polar compounds whereas rising density of the network reduces the accessibility of sorption sites to all solutes. Mini‐cartridges containing 30 mg of an optimal sorbent take up the acids completely and reversibly, the recoveries being close to 100% even in the presence of high concentrations of albumin. By coupling the developed solid‐phase extraction with high‐performance liquid chromatography and diode array detection technique, we managed to determine quantitatively phenylcarboxylic acids in the serum of a healthy patient blood, and the recoveries varied from 93 to 100% while the limit of quantification was (4–9) × 10−7 M.

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