2013
DOI: 10.1007/s12105-013-0476-6
|View full text |Cite
|
Sign up to set email alerts
|

Acetylated Tubulin (AT) as a Prognostic Marker in Squamous Cell Carcinoma of the Head and Neck

Abstract: Acetylated tubulin (AT) expression has been proposed as a marker for sensitivity to taxane chemotherapy. We wanted to explore AT as a prognostic marker in squamous cell carcinoma of the head and neck (SCCHN). We assessed AT expression in archival tissue from our institutional tissue bank of primary SCCHN specimens. We also examined AT expression on pre-therapy tissues of patients with SCCHN receiving induction chemotherapy with docetaxel, cisplatin and 5FU (TPF IC). AT expression was assessed on archival cases… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
26
2
1

Year Published

2015
2015
2024
2024

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 37 publications
(29 citation statements)
references
References 27 publications
0
26
2
1
Order By: Relevance
“…The dependence upon endogenous acetylation for reattachment and chemotaxis of metastatic breast tumor cell lines and the significant increase of α-tubulin acetylation in metastatic tumors support a model in which tubulin acetylation confers a selective advantage for metastatic potential. This model is further supported by very recent evidence that high α-tubulin acetylation is associated with a more invasive phenotype in human pancreatic cancer cell lines (49) as well as lymph node metastasis and poor prognosis in patients with head and neck squamous cell carcinoma (50). …”
Section: Discussionmentioning
confidence: 54%
“…The dependence upon endogenous acetylation for reattachment and chemotaxis of metastatic breast tumor cell lines and the significant increase of α-tubulin acetylation in metastatic tumors support a model in which tubulin acetylation confers a selective advantage for metastatic potential. This model is further supported by very recent evidence that high α-tubulin acetylation is associated with a more invasive phenotype in human pancreatic cancer cell lines (49) as well as lymph node metastasis and poor prognosis in patients with head and neck squamous cell carcinoma (50). …”
Section: Discussionmentioning
confidence: 54%
“…Recently, high level of acetylated tubulin expression have been found correlated with a higher tumor grade in squamous cell carcinoma of the head and neck [57], and its expression has been suggested as a prognostic marker in epithelial malignancies and as a marker for sensitivity to chemotherapy [58]. A relationship between high level of α-tubulin acetylation and metastatic behaviour of basallike breast cancers, it has been also recently reported [59].…”
Section: Discussionmentioning
confidence: 90%
“…GCN5 promotes the G2/M transition by inducing a-tubulin acetylation [25] and the deletion of GCN5 augment cell apoptosis and G2/M retardation [26]. Furthermore, acetylated atubulin is involved in stabilization of a-tubulin, promoting antimitotic drug resistance [27] and aggressiveness of cancers [28].…”
Section: Discussionmentioning
confidence: 99%