2020
DOI: 10.1016/j.canlet.2019.11.043
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Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression

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Cited by 52 publications
(50 citation statements)
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“…The endocytosed AFP (we also call cytoplasmic AFP or AFP briefly) then binds with certain cytoplasmic proteins, leading to the activation or inhibition of signaling pathways. The endocytosed AFP can interact with PTEN and activate the PI3K/AKT/mTOR pathway, which promotes the malignant behavior of hepatocellular carcinoma (HCC) cells by upregulating the protein expression of mTOR (13)(14)(15)(16)(17) (Figure 1).…”
Section: The Role Of Classic Afp Receptors and Afpmentioning
confidence: 99%
“…The endocytosed AFP (we also call cytoplasmic AFP or AFP briefly) then binds with certain cytoplasmic proteins, leading to the activation or inhibition of signaling pathways. The endocytosed AFP can interact with PTEN and activate the PI3K/AKT/mTOR pathway, which promotes the malignant behavior of hepatocellular carcinoma (HCC) cells by upregulating the protein expression of mTOR (13)(14)(15)(16)(17) (Figure 1).…”
Section: The Role Of Classic Afp Receptors and Afpmentioning
confidence: 99%
“…As the bifunctional enzymes, p300 and CBP acetylate histones and act as transcriptional coactivators that regulate cell proliferation and differentiation 39–41 . Thus, the acetylation of p300 and CBP in HCC may alter its activity and regulate oncogene expression 42–44 . However, the significance of the hyperacetylation of p300 and CBP remains unknown.…”
Section: Resultsmentioning
confidence: 99%
“…[39][40][41] Thus, the acetylation of p300 and CBP in HCC may alter its activity and regulate oncogene expression. [42][43][44] However, the significance of the hyperacetylation of p300 and CBP remains unknown.…”
Section: Acetylation Of Histone Acetyltransferases In Hccmentioning
confidence: 99%
“…Cytoplasmic AFP interacts with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), thereby activating the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway and enhancing mTOR. 26 Yen et al 27 showed that HBx upregulated mTOR signaling via IκB kinase β (IKKβ), thereby promoting cell proliferation and production of vascular endothelial growth factor (VEGF). They also showed that the mTOR inhibitor rapamycin suppressed HBx-induced carcinogenesis.…”
Section: Role Of Hbx In Signal Transductionmentioning
confidence: 99%