Acetylation of tamarind seed Jellose

Rao, P. S.; Beri, R. M.

doi:10.1007/bf03053508

Cited by 15 publications

(5 citation statements)

References 4 publications

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“…Scientists were prompted to chemically alter its functional groups due to its insolubility in water and deterioration in an aquatic environment [ 12 ]. Various modifications which have been executed till date include carboxymethylation, acetylation, hydroxyl-alkylation and thiolisation, polymer grafting [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

et al. 2021

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Polymers from natural sources are widely used as excipients in the formulation of pharmaceutical dosage forms. The objective of this study was to extract and further characterize the tamarind gum polysaccharide (TGP) obtained from Tamarindus indica as an excipient for biomedical applications. Double distilled water was used as a solvent for the extraction of gum while Ethyl alcohol was used as an antisolvent for the precipitation. The results of the Hausner ratio, Carr’s index and angle of repose were found to be 0.94, 6.25, and 0.14, respectively, which revealed that the powder is free-flowing with good flowability. The gum was investigated for purity by carrying out chemical tests for different phytochemical constituents and only carbohydrates were found to be present. The swelling index was found to be 87 ± 1%, which shows that TGP has good water intake capacity. The pH of the 1% gum solution was found to be neutral, approximately 6.70 ± 0.01. The ash values such as total ash, sulphated ash, acid insoluble ash, and water-soluble ash were found to be 14.00 ± 1.00%, 13.00 ± 0.05%, 14.04 ± 0.57% and 7.29 ± 0.06%, respectively. The IR spectra confirmed the presence of alcohol, amines, ketones, anhydrides groups. The contact angle was <90°, indicating favorable wetting and good spreading of liquid over the surface The scanning electron micrograph (SEM) revealed that the particle is spherical in shape and irregular. DSC analysis shows a sharp exothermic peak at 350 °C that shows its crystalline nature. The results of the evaluated properties showed that TGP has acceptable properties and can be used as a excipient to formulate dosage forms for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

et al. 2021

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“…However, because of several drawbacks, such as unpleasant odor, dull color, presence of water insolubles, low solubility in cold water, and fast biodegradability, its various derivatives e.g. acetyl, hydroxyalkyl and carboxymethyl [ 9 , 10 ] have been prepared. Carboxymethyl tamarind kernel powder (CMTKP) is a carboxymethylated derivative of tamarind kernel powder.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Carboxymethyl Tamarind Kernel Powder Interpolymer Complexation: Investigations for Colon Drug Delivery

Kaur

2010

Sci. Pharm.

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The present study was aimed at evaluating the possible use of inter polymer complexed (IPC) films of chitosan (CH) and carboxymethyl tamarind kernel powder (CMTKP) for colon release of budesonide. Viscosity analysis of the supernatant liquid obtained after reacting CH and CMTKP in different proportions revealed 40:60 to be the optimum stoichiometric ratio. The FTIR spectra of IPC films formed from 50:50 or 40:60 ratio of CH:CMTKP did not reveal any reduction in the peaks at 1560cm−1 and 1407cm−1 after exposure to pH 1.2, suggesting resistance of the interaction between −COO− groups of CMTKP and −NH3+ groups of CH to gastric pH. Tablets containing Avicel pH 102 as diluent and coated to a weight gain of 10%, w/w with aqueous solutions of 40:60 or 50:50 ratio of CH:CMTKP did not release budesonide in pH 1.2 buffer. Histopathology of the rat colon after oral administration of these IPC film coated tablets revealed significantly greater (p<0.05) reduction in TNBS-induced ulcerative colitis as compared to that after administration of uncoated tablets. The Cmax of budesonide achieved after oral administration of these IPC film coated tablets was comparable to that observed after administration of uncoated tablets. The results strongly indicate versatility of CH-CMTKP IPC films to deliver budesonide in the colon.

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“…Its insolubility in water and degradation in an aqueous environment has forced the scientists to chemically modify its functional groups [46] . Various modifications which have been executed till date include carboxymethylation [47] , acetylation [48] , hydroxylalkylation [49] and thiolisation [50,51] . Such modifications have caused alteration in the solubility, viscosity, swelling and stability of TG.…”

Section: Chemical Modification Of Tgmentioning

confidence: 99%

“…Acetylation of TG can be done with glacial acetic acid and anhydrous sodium acetate. The acetyl derivative of TG is hydrophobic in nature [48] .…”

Section: Acetylation Of Tgmentioning

confidence: 99%

Delivery of drugs using tamarind gum and modified tamarind gum: A review

Mali¹,

Dhawale²,

Dias³

et al. 2019

Bulletin of Faculty of Pharmacy, Cairo University

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Tamarind seed polysaccharide is an emerging excipient, which is being used and investigated for the preparation of various dosage forms. Functionalization of tamarind gum (TG) enhances the properties of native tamarind polysaccharide like degradability, hydration, viscosity and swelling. Due to these excellent properties, researchers investigated the application of modified TG in various drug delivery systems. TG and modified TG are found to be appropriate for the designing of oral, nasal, ophthalmic, colonic and topical drug delivery systems. Moreover, they are used in the preparation of hydrogel-based drug delivery systems and novel drug delivery systems such as nanoparticles. Considering the above facts, additional research work is required to confirm the pharmaceutical uses of TG and modified TG in drug delivery. The current review deals with a comprehensive and valuable discussion on pharmaceutical applications of TG and modified TG.

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Acetylation of tamarind seed Jellose

Cited by 15 publications

References 4 publications

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

Chitosan-Carboxymethyl Tamarind Kernel Powder Interpolymer Complexation: Investigations for Colon Drug Delivery

Delivery of drugs using tamarind gum and modified tamarind gum: A review

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