Acetylator phenotypes: Effect of age

Abstract

The distribution of acetylator phenotypes in a Hungarian population of 253 Caucasian was studied. The patients were divided into two age groups - the elderly over 60 years, and young below that age. The individuals below the age of 60 years contained an equal proportion of the two acetylator phenotypes. The same distribution was observed in the population as a whole. In the elderly subjects the slow acetylator phenotype was predominant. The finding supports the hypothesis that age has an influence on hepatic drug acetylation rate.

Influence of age, sex and body weight on the dapsone acetylation phenotype.

“…Although it is recognised that the activities of hepatic microsomal enzymes are modulated by factors such as age, sex, diet, disease, medication and environmental exposures (Vesell, 1982) little is known about the influence of such factors on NAT activity. Recently several studies have given contradictory results on the influence of age and sex on the acetylation phenotype (Gachalyi et al, 1984;Paulsen & Nilsson, 1985;Pontiroli et al, 1985).…”

N‐acetylation and serotonergic measures in a group of psychiatric patients

“…Our patient population was comparatively young, and this could be the reason why our results differ from a study conducted by Paulsen & Nilsson (23). Similarly, another study showed a predominance of slow acetylator phenotype in ages above 60 (24). Similarly, another study showed a predominance of slow acetylator phenotype in ages above 60 (24).…”

“…In this study, males, especially in old age, were significantly slower than females. Similarly, another study showed a predominance of slow acetylator phenotype in ages above 60 (24). Acetylator phenotypes show wide variations in different ethnic groups around the world (4, 21).…”

Zusammenhang der Serum- und Synovialflüssigkeitskonzentrationen des Sulfasalazins und dessen Hauptmetaboliten, des Azetylierer-Phänotyps und der Nebenwirkungen bei der chronischen Polyarthritis

“…Die Auswahl der Patienten beruhte auf der Grundlage, daß ihr Alter und Körpergewicht annähernd identisch waren. Es ist bekannt, daß sich das Verhältnis der langsamen Azetylierer über 60 Jahre erhöht (13), das zwischen 24 und 46 Jahre liegende Alter der in die Untersuchung einbezogenen Patienten konnte jedoch die den Metabolismus eventuell beeinflussende Wirkung des Alters sicherlich ausschließen. Infolge des zwischen 58 und 73kg betragenden Körpergewichts der Patienten war die Dosismenge je Körpergewicht-Kilogramm in sämtlichen Fällen annähernd gleich groß, täglich 2g SASP durchschnittlich entsprach einer Dosis von 30 mg/kg Körpergewicht.…”