Acetylcholine and cholinesterases (assays and light- and electron microscopical histochemistry) in different parts of the pituitary of rat, rabbit and domestic pig

Bridges, T. E.; Fisher, Avraham; Gosbee, J. L.; Lederis, K.; Santolaya, R. C.

doi:10.1007/bf00307676

Cited by 24 publications

(6 citation statements)

References 25 publications

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“…The PI is rich in noradrenaline (NA) [Bjorklund et al, 1970;BjOrklund et al, 1973;Jacobowitz, 1973;Saavedra etal., 1975], dopamine (DA) [Bjork lund, 1968;Bjorklund et al, 1970;Baumgarten etal., 1972;Bjorklund et al, 1973;Jacobowitz, 1973;Saavedra et al, 1975], 5-hydroxytryptamine (5-HT) [Piezzi and W urtman, 1970;Hyyppa and Wurtman, 1973;Jaco bowitz, 1973;Saavedra et al, 1975], and histamine (HA) [Saavedra et al, 1975], and has high levels of acetylcholine and acetylcholinesterase activity [Bridges et al, 1973;Whitaker and Labella, 1973].…”

Section: Discussionmentioning

confidence: 99%

In vitro Release of ACTH from Dispersed Rat Pars Intermedia Cells. II. Effect of Neurotransmitter Substances

Kraicer¹,

Morris²

1976

Neuroendocrinology

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Studies were carried out to test the responsiveness of dispersed pars intermedia (PI) cells to a number of neurotransmitter substances known to be present in the PI. These substances were tested over an extended dose range. The catecholamines, adrenaline, noradrenaline, and dopamine inactivated PI ACTH at high concentrations; at lower concentrations, they were without effect. Histamine and carbachol had no effect on ACTH release. 5-hydroxytryptamine stimulated ACTH release in a dose-related manner, from 10^–6 to 10^–3M, while having no effect on ACTH release from the pars distalis (PD). We conclude that the release of ACTH from the PI may be controlled by direct serotonergic innervation.

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Section: Discussionmentioning

confidence: 99%

In vitro Release of ACTH from Dispersed Rat Pars Intermedia Cells. II. Effect of Neurotransmitter Substances

Kraicer¹,

Morris²

1976

Neuroendocrinology

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“…( Bridges et al, 1973; Bjo r k l u n d et al., 1973]. Could ACTH secretion from the PI be controlled by a direct neuronal mechanism, rather than via the hypophysial portal circulation?…”

Section: Discussionmentioning

confidence: 99%

In vitro Release of ACTH from Dispersed Rat Pars Intermedia Cells. I. Effect of Secretagogues

Kraicer¹,

Morris²

1976

Neuroendocrinology

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Studies were made to test the responsiveness of dispersed pars intermedia (PI) cells to a number of secretagogues that are known to alter ACTH release from the pars distalis (PD) in vitro. In summary, (a) incubation in high [K+], which will increase ACTH release from the PD, did not alter ACTH release from the PI; (b) a crude extract of rat hypothalamus (HE) increased ACTH release from PD and PI; (c) the effect of HE was not due to its vasopressin content, since pretreatment of the extract with thioglycolic acid did not modify its ACTH-releasing activity and neither lysine nor arginine vasopressin stimulated ACTH release from the PI; and (d) a partially purified CRF preparation, which will stimulate ACTH release from the PD, did not alter ACTH release from the PI. We conclude that the hypothalamus contains a substance(s) that will stimulate ACTH release from the PI and that the ‘secretagogue’ is neither vasopressin nor the same CRF that will stimulate ACTH release from the PD.

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“…However, it is difficult to find the coated vesicles derived from the limiting membrane, which they described. UEMURA (1965), LEDERIS and LIVINGSTON (1966, 1969 reported the occurrence of acetylcholine in the neurohypophysis biochemically, while BRIDGES et al (1973) considered that cholinesterase and acetylcholine in this part, which are very little in quantity, do not play so important a role for the release of the posterior lobe hormones.…”

Section: Small Vesiclesmentioning

confidence: 99%

Some Findings on the Fine Structure of the Neurohypophysis in Dehydrated and Pitressin-Treated Mice

Kodama

Fujita

1975

Arch. Histol. Jap., Arch. Histol. Jpn

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Acetylcholine and cholinesterases (assays and light- and electron microscopical histochemistry) in different parts of the pituitary of rat, rabbit and domestic pig

Cited by 24 publications

References 25 publications

<i>In vitro</i> Release of ACTH from Dispersed Rat Pars Intermedia Cells. II. Effect of Neurotransmitter Substances

<i>In vitro</i> Release of ACTH from Dispersed Rat Pars Intermedia Cells. II. Effect of Neurotransmitter Substances

<i>In vitro </i>Release of ACTH from Dispersed Rat Pars Intermedia Cells. I. Effect of Secretagogues

Some Findings on the Fine Structure of the Neurohypophysis in Dehydrated and Pitressin-Treated Mice

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