Acetylcholinesterase inhibitors from galbanum, the oleo gum-resin of Ferula gummosa Boiss.

Adhami, Hamid-Reza; Fitz, Veronika; Lubich, Andrea; Kaehlig, Hanspeter; Zehl, Martin; Krenn, Liselotte

doi:10.1016/j.phytol.2014.08.023

Cited by 27 publications

(16 citation statements)

References 23 publications

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“…It seems possible that these compounds are hydroxylated sesquiterpene coumarin ethers, but their structure elucidation proved difficult. Even though electrospray ionization is a fairly gentle ionization method and usually produces [ M +H] + ions, it has been reported that for many hydroxylated monoterpene and sesquiterpene coumarins the quasi ‐molecular ion is not seen in LC‐ESI‐MS analyses . Instead, the most abundant ions are formed by the cleavage of OH group(s) or are adduct ions.…”

Section: Resultsmentioning

confidence: 99%

Profiling of Coumarins in Peucedanum palustre (L.) Moench Populations Growing in Finland

Yrjönen

Eeva

Kauppila

et al. 2016

Chemistry & Biodiversity

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The coumarin composition of Peucedanum palustre (L.) Moench populations growing in Finland was investigated. A total of 132 flowering P. palustre specimens from 43 locations in southern and central Finland were collected, divided into root, stem, leaf, and umbel samples, and analyzed by HPLC. HPLC coupled to high-resolution mass spectrometry was used to aid the identification of coumarins. A total of 13 coumarin-structured compounds were quantitatively analyzed from the samples. The coumarin profile of root samples was found to differ from the aerial plant parts. The main coumarins in roots were oxypeucedanin and columbianadin. In aerial parts, peulustrin isomers were the most abundant coumarin components. Umbels and leaves also contained a considerable amount of umbelliprenin, which was only found in traces in roots. Based on hierarchical cluster analysis of the coumarin profiles, some populations shared common characteristics. The most distinct property connecting certain populations was their high peulustrin content. Another notable common property between some populations was the high umbelliprenin content in aerial plant parts. Some populations were clustered together due to their low overall coumarin content.

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Section: Resultsmentioning

confidence: 99%

Profiling of Coumarins in Peucedanum palustre (L.) Moench Populations Growing in Finland

Yrjönen

Eeva

Kauppila

et al. 2016

Chemistry & Biodiversity

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“…persica and F. halophila, as well as the hexane extract of F. elaeochytris, were assigned to be more active than methanolic extracts of the plants [36][37][38]. In addition, the acetylcholinesterase inhibitory activities of coumarin derivatives from F. gummosa and F. asafoetida species were determined, previously [30][31][32][33][34][35][36][37][38][39][40][41]. In the current study, the chloroform extracts of F. caspica and F. halophila that could be expected to contain some coumarin derivatives weren't found to be as active as methanol extracts of the plants compared to standard donepezil.…”

Section: Discussionmentioning

confidence: 99%

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Kahraman¹,

Baysal²,

Cankaya³

et al. 2019

jrp

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The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants' extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

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“…The search for AChE inhibitors has been biased towards alkaloids (Elgorashi and Van Staden, ; Elgorashi et al , ; Houghton et al , ; Adewusi et al , ), even though other phytochemicals such as sterols, terpenoids, oils, flavonoids and other phenolic compounds have also been suggested, and in some instances, shown to possess anti‐AChE properties (Ji and Zhang, ; Sacan and Yanardag, ). Besides alkaloids (Elgorashi et al , ; Houghton et al , ; Nair et al , ; Nair and Van Staden, ), coumarins (Kang et al , ; Fallarero et al , ; Senol et al , ; Adhami et al , ) and other compounds such as 5‐HMF (Liu et al , ; Zhao et al , ) and flavonoids (Maryam et al , ) have been shown to exhibit AChE inhibitory properties. The present study explored the main phenolic acids and flavonoid constituents in the different parts of C .…”

Section: Discussionmentioning

confidence: 99%

“…Inhibition of AChE, a key enzyme in the hydrolysis of acetylcholine, a critical neurotransmitter in the brain, has become one of the primary strategies in the management of several debilitating neurological disorders such as AD, which is the most common form of dementia (Sacan and Yanardag, 2010;Adewusi et al, 2011). Thus, increasing the levels of acetylcholine through the inhibition of AChE has been shown to restore normal cholinergic function for symptomatic relief of mild to moderate AD (Fallarero et al, 2008;Adhami et al, 2014). In the present study, crude extracts of C. vansonii, in particular roots and rhizomes, exhibited potential as a source of AChE inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Characterization, Antibacterial, Acetylcholinesterase Inhibitory and Cytotoxic Properties of Cryptostephanus vansonii, an Endemic Amaryllid

Moyo

Aremu

Chukwujekwu

et al. 2017

Phytotherapy Research

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Cryptostephanus vansonii I. Verd., an endemic Amaryllidaceae species from Zimbabwe, was evaluated for its acetylcholinesterase (AChE) inhibitory and cytotoxicity properties using Ellman's colorimetric method and the tetrazolium-based colorimetric assay against Vero monkey kidney cells, respectively. The plant extracts were also evaluated for their antibacterial activity against five bacteria. Furthermore, phytochemical profiles of the extracts were determined using ultra-high performance liquid chromatography coupled with tandem mass spectrometry analysis. A plant part-dependent AChE inhibitory activity was observed, in the order, root > rhizome > basal leaf > leaf. Overall, C. vansonii extracts exhibited better antibacterial activity against Gram-negative compared with Gram-positive bacteria. Cytotoxic effects were not detected in Vero monkey kidney cell lines suggesting the possible absence of toxophores in C. vansonii extracts. Similar to the trend in biological activity, a distinct plant part-dependent variation in hydroxybenzoates, hydroxycinnamates and flavonoids was observed in the plant extracts. In addition, 5-hydroxymetylfurfural and eucomic acid were detected in the different plant parts of C. vansonii. The results of the present study provide valuable AChE inhibition activity, toxicological and phytochemical profiles of C. vansonii. Further studies on isolation of bioactive compounds and their subsequent evaluation in other pharmacological and toxicological model systems are required. Copyright © 2017 John Wiley & Sons, Ltd.

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Acetylcholinesterase inhibitors from galbanum, the oleo gum-resin of Ferula gummosa Boiss.

Cited by 27 publications

References 23 publications

Profiling of Coumarins in Peucedanum palustre (L.) Moench Populations Growing in Finland

Profiling of Coumarins in Peucedanum palustre (L.) Moench Populations Growing in Finland

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Phytochemical Characterization, Antibacterial, Acetylcholinesterase Inhibitory and Cytotoxic Properties of Cryptostephanus vansonii, an Endemic Amaryllid

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