Acetylcholinesterase inhibitory activity of stigmasterol &amp; hexacosanol is responsible for larvicidal and repellent properties of Chromolaena odorata

Gade, Sriramya; Rajamanikyam, Maheshwari; Vadlapudi, Varahalarao; Nukala, Krishna Madhav; Aluvala, Rajendar; Chandrasekhar, G.; Karanam, Naga Jyothi; Barua, Nabin C.; Pandey, Rashmi; Upadhyayula, Vijaya Saradhi Vr; Prabhakar, S.; Amanchy, Ramars; Upadhyayula, Suryanarayana Murty

doi:10.1016/j.bbagen.2016.11.044

Cited by 67 publications

(32 citation statements)

References 41 publications

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“…15 The inhibition of acetylcholinesterase is the major mode of action for most insecticides especially organophosphates and carbamates, and this effect may be responsible for larvicidal activity on against Culex quinquefasciatus, Culex pipiens, Anopheles gambiae and Aedes aegypti. 16,17 In this context, the aims of this study was to obtain derivatives of carvacrol/thymol and to investigate the inhibitory activity of acetylcholinesterase and larvicidal against Aedes aegypti larvae. The synthesis of the compounds was carried out according to the procedure shown in Figures 1 and 2.…”

Section: -14mentioning

confidence: 99%

Synthesis, Larvicidal and Acetylcholinesterase Inhibitory Activities of Carvacrol/Thymol and Derivatives

Mesquita¹,

Nascimento²,

Souza³

et al. 2018

Quim. Nova

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In order to produce bioactive derivatives of carvacrol and thymol, nine derivatives of each compound were prepared through modifications the phenolic hydroxyl group. The structures of compounds were confirmed by spectral data from MS, IR and NMR. Carvacrol, thymol and derivatives were submitted to the evaluation of the inhibition of the enzyme acetylcholinesterase, using a colorimetric method in which the inhibition of the enzyme is measured by coloration, and larvicidal activity against Aedes aegypti. Derivatives carvacryl acetate-1b and thymyl hexanoate-2b showed the best results for the inhibition of the acetylcholinesterase enzyme, and for the larvicidal activity the derivatives 1a, 1b, 1c, 3h, 2a, 2b, 2c and 4h showed positive results, emphasizing compound thymyl 4-methoxybenzoate-4h which showed LC 50 values of 23.60 ppm, considered a very good result.

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Section: -14mentioning

confidence: 99%

Synthesis, Larvicidal and Acetylcholinesterase Inhibitory Activities of Carvacrol/Thymol and Derivatives

Mesquita¹,

Nascimento²,

Souza³

et al. 2018

Quim. Nova

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“…C. odorata is widely used in folklore medicine. There are many reports on the pharmaceutical applications of C. odorata using different solvents (Hanh et al, 2011;Akinmoladun et al, 2010;Pandith et al, 2012;Gade et al, 2017). The medical importance of the weed is reviewed by Vijayaraghavan et al, (2017).…”

Section: Introductionmentioning

confidence: 99%

Comparative studies on phytochemistry, antioxidant and antibacterial activity of direct and sequential extracts of chromolaena odorata leaves

Sriraman

Shanmugasundaram

et al. 2019

ijrps

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Phytochemistry, antioxidant and antibacterial activities of different solvent extracts of Chromolaena odorata leaves obtained by direct and sequential extraction were compared in this study. Antibacterial evaluation of the extracts was performed through a disc diffusion method. The results revealed that the solvents, Petroleum ether and Ethyl acetate showed the presence of a majority of the phytochemicals, Chloroform extract yielded maximum TPC and TAA and ethyl acetate yielded higher TFC when compared to other solvents. Ethanol and chloroform extracts showed lower concentrations of IC50 against DPPH and NO radicals respectively. Acetone recorded the maximum zone of inhibition against Staphylococcus aureus and Pseudomonas aeruginosa; ethyl acetate against Bacillus subtilis and Chloroform against Streptococcus mutans. Among the solvents studied for phytochemical content and bioactivities, ethanol showed a higher level of phytochemical extraction and better bioactivities. As a direct solvent extraction of C. odorata showed better efficiency when compared with sequential extraction, the study strongly recommends the use of a direct extraction method.

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“…Acetylcholinesterase (AChE) is an enzyme that hydrolyses the acetylcholine and other choline esters that function as neurotransmitters in chemical synapses. Their inhibitors increase the neurotransmitter action, and so they are used as insecticides [ 27 ] and in the treatment of cancer [ 28 ] and Alzheimer's disease [ 29 , 30 ]. Some studies about TmEO from Portugal reported the inhibition of LOX and AChE [ 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Thymus mastichina L. essential oils from Murcia (Spain): Composition and antioxidant, antienzymatic and antimicrobial bioactivities

et al. 2018

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The compositions of essential oils (EOs) from Spanish marjoram (Thymus mastichina L.) grown in several bioclimatic zones of Murcia (SE Spain) were studied to determine their absolute and relative concentrations using gas chromatography-mass spectrometry. 1,8-Cineole and linalool were the main components, followed by α-pinene, β-pinene and α-terpineol. (–)-Linalool, (+)-α-terpineol and (+)-α-pinene were the most abundant enantiomers. When the antioxidant capacities of T. mastichina EOs and their compounds were measured by five methods, EOs and linalool, linalyl acetate, α-terpinene and γ-terpinene, among others, showed antioxidant activities. All four T. mastichina EOs inhibited both lipoxygenase and acetylcholinesterase activities, and they might be useful for further research into inflammatory and Alzheimer diseases. Bornyl acetate and limonene showed the highest lipoxygenase inhibition and 1,8-cineole was the best acetylcholinesterase inhibitor. Moreover, these EOs inhibited the growth of Escherichia coli, Staphylococcus aureus and Candida albicans due to the contribution of their individual compounds. The results underline the potential use of these EOs in manufactured products, such as foodstuff, cosmetics and pharmaceuticals.

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Acetylcholinesterase inhibitory activity of stigmasterol & hexacosanol is responsible for larvicidal and repellent properties of Chromolaena odorata

Cited by 67 publications

References 41 publications

Synthesis, Larvicidal and Acetylcholinesterase Inhibitory Activities of Carvacrol/Thymol and Derivatives

Synthesis, Larvicidal and Acetylcholinesterase Inhibitory Activities of Carvacrol/Thymol and Derivatives

Comparative studies on phytochemistry, antioxidant and antibacterial activity of direct and sequential extracts of chromolaena odorata leaves

Thymus mastichina L. essential oils from Murcia (Spain): Composition and antioxidant, antienzymatic and antimicrobial bioactivities

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