Acetylsalicylic Acid (ASA) on Hydroxyethylcellulose/Polyacrylamide Gel (HEC/PAAm) as a Proposal for a Dermatological Compress: Mathematical Modeling of ASA Release Kinetics

Abstract

Currently, acne in adolescents and adults is caused by an infection in follicles caused by hormonal changes, stress, water pollution, air, and earth; the last one comes into contact with the skin through the hands of patients. This project presents the incorporation of acetylsalicylic acid (ASA) to the hydroxyethylcellulose/polyacrylamide gel (HEC/PAAm) in the synthesis of gel or by its swelling.The results show us that the incorporation of ASA is possible by both methods; first, the incorporation by synthesis of degradation of the gel is more visible. The infrared spectroscopic analysis shows the functional groups of gel and ASA, 2921 and 2863 cm −1 , whose assignments correspond to CH 3 and CH 2 groups, which are part of both the polymer and the ASA molecule, which confirms the interaction between the two groups. The microscopy photographs (SEM) show on the surface the drug in irregular whitish orthorhombic forms due to swelling; arborescent structures are observed in the case of the incorporation of the ASA drug by synthesis. Swelling kinetics has a Fickian form. The Higuchi model conforms to the release of ASA because the level of confidence is 90%. This gel was allowed to release 0.35 mg/hour, thus allowing the patient to have a continuous form of the release, in the affected area in a short period of time.

Morphological and Electrical Properties of Nanocellulose Compounds and Its Application on Capacitor Assembly

“…The images were analyzed using the software Gwyddion 2.47. The electrical 15. A small piece of the films was cut, and it was placed on carbon tape.…”

Mathematical Modelling of Acetaminophen Release in HPC/PAAm Hydrogel: Synthesis and Application

“…This mathematical model allows to simulate the concentrations of released acetaminophen even at times beyond the tested and to predict the moment in which the drug release will be finished. Figure 9 shows, in black, the simulation for the release of acetaminophen from HPC/PAAm gel in PBS at any of the three evaluated temperatures, obtained with Equation (7). The red lines in the same figure represent the experimental data at each temperature.…”

“…Currently, numerous scientific researches on hydrogels as Drug Delivery Systems have been reported in [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Hydroxypropyl cellulose with polyacrylamide (HPC/PAAm) is a particularly interesting hydrogel because it is biodegradable.…”

“…Besides, other polymers have also presented drug crystallization on the surface. Castillo-Miranda et al [7] reported the formation of acetylsalicylic acid crystals on the surface of hydroxyethyl cellulose/polyacrylamide gel; they also observed a smooth surface formed by the cellulose derivative. Orthorhombic crystals were also observed on the surface, with larger crystals in the range of 4-10 μm; this morphology is a stable polymorph of acetaminophen at room temperature [34].…”

“…Micrographs of the surface of HPC/PAAm gel with incorporated acetaminophen: (a) 100x, (b) 500x, and (c) 1500x.7International Journal of Polymer Science the beginning of the process, a population size of 100 function trees, and a maximum of 200 iterations. The representative mathematical model for the three experimental temperatures can be described by Equation(7). The coefficients of determination R 2 and adjusted R 2 are calculated as 0.98849 and 0.98795, respectively: y = 26:3 * tanh 0…”