Acetylsalicylsäure als Augmentationsfaktor einer Nahrungsmittel-Allergie

Abstract

A 39-year-old female patient presented with an intense allergic reaction and shock after ingesting sunflower seeds and simultaneously acetylsalicylic acid (ASA). Skin tests and CAP specific. IgE demonstrated an IgE-mediated sensibilization to sunflower seeds. When sunflower seeds were eaten alone, only discrete paresthesia of the oral mucosa occurred. Surprisingly, an oral challenge with ASA was well tolerated. The supplementary contribution of ASA to the allergic reaction was dose-dependent. The quantity of the allergen also modified the intensity of the symptoms. This surprising effect of ASA may be attributed to increased gastric resorption of the allergens. During the course of this reaction, eosinophil-cationic-protein was released.

Ethanol as a cause of hypersensitivity reactions to alcoholic beverages

“…The finding of an increased sLT production by ethanol in some DBPCFC‐negative patients may be also explained by the possible necessity of an cofactor. The observation that some hypersensitivity reactions are induced only in the presence of cofactors is well known for exercise [18] or drugs [19], but a complex phenomenon involving several mechanisms has also been suggested to play a role in wine‐induced asthma [5]. Although other ingredients of alcoholic beverages such as FAs [4, 6] or cereals (in beer) [7–9] have been shown to elicit adverse reactions, in our patients, FAs were only relevant in the one patient who refused ethanol challenge.…”

Review of cold-induced urticaria characteristics, diagnosis and management in a Western Canadian allergy practice

“…One retrospective study from Spain and Portugal showed that nearly 20% of their patients with cold-induced urticaria presented with life threatening reactions to the cold [3]. It is a relatively rare disorder with a reported prevalence of 0.05% as per one study in Europe, with a higher prevalence in northern climates [4]. It is also self-limited, lasting 4–5 years on average.…”

Acetylsalicylic acid dependent anaphylaxis to carrots in a patient with mastocytosis

“…Möller and colleagues reported a woman who had an attack of anaphylaxis after consuming sunflower seeds and acetylsalicylic acid. Given that in both patients exposure to acetylsalicylic acid alone did not elicit an allergic reaction, and that the triggering foodstuffs alone caused only mild oral allergy syndrome, the authors suggested that acetylsalicylic acid may enhance intestinal absorption of the allergen [7,8]. Matsuo and colleagues showed that, with the combination of wheat and physical exertion or acetylsalicylic acid, serum gliadin levels were significantly higher than when wheat was consumed alone without any other triggering co-factors [9].…”