Achievement of saturation targets in preterm infants &lt;32 weeks’ gestational age in the delivery room

White, Lani Nui; Thió, Marta; Owen, Louise; Kamlin, C. Omar F.; Sloss, Samantha; Hooper, Stuart B.; Davis, Peter G; Dawson, Jennifer A

doi:10.1136/archdischild-2015-310311

Cited by 34 publications

(37 citation statements)

References 22 publications

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“…Such data showed that preductal peripheral capillary oxygen saturation (SpO 2 ) increased only gradually over 10 min of life 91,92 and that using 100% oxygen for respiratory support led to a more rapid increase in SpO 2 than was observed during normal transition of the healthy infant. 30,93 Despite this, the optimum evolution of SpO 2 following a pathological birth such as birth asphyxia or preterm delivery is unknown and could be very different to that of normal, full-term and healthy infants.…”

Section: Human Datamentioning

confidence: 99%

Oxygen therapy of the newborn from molecular understanding to clinical practice

et al. 2018

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Oxygen is one of the most critical components of life. Nature has taken billions of years to develop optimal atmospheric oxygen concentrations for human life, evolving from very low, peaking at 30% before reaching 20.95%. There is now increased understanding of the potential toxicity of both too much and too little oxygen, especially for preterm and asphyxiated infants and of the potential and lifelong impact of oxygen exposure, even for a few minutes after birth. In this review, we discuss the contribution of knowledge gleaned from basic science studies and their implication in the care and outcomes of the human infant within the first few minutes of life and afterwards. We emphasize current knowledge gaps and research that is needed to answer a problem that has taken Nature a considerably longer time to resolve.

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Section: Human Datamentioning

confidence: 99%

Oxygen therapy of the newborn from molecular understanding to clinical practice

et al. 2018

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“…Die Kriterien zum Abnabeln waren hier folgende [10]: ▪ adäquat erscheinende Atmung, respektive Lungenbelüftung (mittleres exspiratorisches Atemzugvolumen Tv ≥ 4 ml / kg) unter CPAP-Applikation ▪ Herzfrequenz > 100 Schläge / min ▪ SpO2 > 25. Perzentile bei FiO2 < 0,4 [38] Dabei verwendete die Arbeitsgruppe einen speziell konstruierten Erstversorgungsplatz mit dem Namen "Concord", der sich in unmittelbarer Nähe der gebärenden Mutter befand.…”

Section: Studie Zur Erstversorgung Bei Intakter Nabelschnurunclassified

Verzögertes Abnabeln – Frauen kompetent beraten

Kalbér¹,

Kuhn²

2019

Hebamme

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“…Bayi prematur yang lahir dengan kondisi anatomis paru yang belum sempurna memiliki risiko yang tinggi untuk mendapatkan bantuan resusitasi aktif. [1][2][3][4] Penggunaan oksigen 100% saat resusitasi neonatus akan mempercepat peningkatan saturasi perifer, tetapi dapat dengan cepat pula menyebabkan hiperoksia, menyebabkan stress oksidatif dan kerusakan jaringan yang akan meningkatkan morbiditas dan mortalitas, terutama pada bayi prematur. [1][2][3] Berbagai studi dan meta analisis menunjukkan bahwa resusitasi neonatus cukup bulan dengan menggunakan udara ruang sama efektifnya dengan konsenstrasi oksigen 100%.…”

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“…Badan internasional seperti international liaison committee on resuscitation (ILCOR) dan world health organisation (WHO) merekomendasikan konsentrasi oksigen 21% (udara ruang) untuk resusitasi pada bayi cukup bulan dan prematur. [1][2][3][4][5] Berdasarkan hal tersebut maka diajukan pertanyaan sebagai berikut? Berapakah konsentrasi oksigen inisial yang tepat untuk resusitasi pada bayi prematur dengan mempertimbangkan efek jangka panjang pada bayi?…”

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“…Bayi prematur secara umum mendapatkan suplementasi oksigen untuk mencapai saturasi perifer sesuai dengan bayi cukup bulan. 4 The premature infants resuscitated with oxygen or air (PRESOX) trial, yang direncanakan merekrut 1260 bayi merupakan uji klinis pada bayi prematur yang akan menilai penggunaan oksigen konsentrasi rendah dan tinggi untuk inisial resusitasi. Uji ini rencananya akan menggunakan target saturasi oksigen dalam 15 hingga 20 menit pertama dan membandingkan antara konsentrasi oksigen inisial yang rendah dan tinggi.…”

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Mortalitas dan Morbiditas pada Bayi Prematur dengan Resusitasi Menggunakan Oksigen Konsentrasi Rendah

Munadzilah

Dewi

2018

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Latar belakang. Bayi prematur merupakan kelompok yang berisiko membutuhkan bantuan resusitasi aktif. Selama bertahun-tahun, resusitasi neonatus menggunakan oksigen hingga konsentrasi 100%, tetapi penggunaan oksigen 100% akan menyebabkan stres oksidatif dan kerusakan jaringan yang akan meningkatkan morbiditas dan mortalitas. Akhir-akhir ini, penggunaan oksigen konsentrasi rendah (21%-30% ) mulai dianjurkan. Tujuan. Mengetahui mortalitas dan morbiditas bayi prematur yang mendapatkan resusitasi neonatus dengan oksigen konsentrasi rendah dibandingkan konsentrasi tinggi. Metode. Penelusuran pustaka database elektronik: PubMed, Cochrane, Google scholar, dan melalui penulis. Hasil. Didapatkan dua studi meta analisis yang relevan dan satu studi acak terkontrol. Studi pertama menunjukkan tidak ada perbedaan mortalitas dan morbiditas pada kedua kelompok. Studi kedua menunjukkan tidak ada perbedaan mortalitas antara kedua kelompk, tetapi kejadian displasia bronkopulmonar lebih rendah pada kelompok konsentrasi oksigen rendah (RR=0,62). Studi terakhir menunjukkan bahwa resusitasi neonatus dengan oksigen hingga konsentrasi 50% masih aman digunakan. Kesimpulan. Resusitasi neonatus menggunakan oksigen konsentrasi rendah tidak lebih inferior dibandingkan konsnetrasi tinggi, bahkan menurunkan angka kejadian displasia bronkopulmonar. Sari Pediatri 2017;19(3):166-71Kata kunci: resusitasi neonatus, prematur, konsentrasi oksigen, mortalitas dan morbiditas Mortality and Morbidity of Preterm Neonates With Resuscitation Using Low Oxygen concentrationSyarimonitha Munadzilah, Rosalina Dewi Background. Preterm neonates are at risk for active resuscitation. Over the years, neonatal resuscitation uses oxygen up to 100% concentration but this concentration will lead to oxidative stress and tissue damage that will increase morbidity and mortality. Lately the use of low oxygen concentration (21% -30%) is recommended. Objective. Determine the mortality and morbidity of preterm neonates who get neonatal resuscitation with low oxygen concentrations compared to high oxygen concentrations. Methods. Literature research using electronic database: PubMed, Cochrane, Google scholar and through authors. Results. There were two relevant meta-analysis studies and 1 randomized controlled study. The first study showed no differences in mortality and morbidity in both groups. The second study showed no difference in mortality between the two groups, but the incidence of bronchopulmonary dysplasia was lower in the low oxygen concentration group (RR 0.62). Recent studies have shown that neonatal resuscitation with oxygen up to 50% concentration is still safe to use. Conclusion. Neonatal resuscitation using low-concentration oxygen is not inferior than high-oxygen concentration. Low oxygen concentration was more safe and lowering the incidence of bronchopulmonary dysplasia. Sari Pediatri 2017;19(3):166-71

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Achievement of saturation targets in preterm infants <32 weeks’ gestational age in the delivery room

Abstract: Preterm infants spent almost two-thirds of the first 10 min after birth with oxygen saturations outside prescribed target ranges. New titration strategies are required to reduce the risks of hypoxia and hyperoxia.

Cited by 34 publications

References 22 publications

Oxygen therapy of the newborn from molecular understanding to clinical practice

Oxygen therapy of the newborn from molecular understanding to clinical practice

Verzögertes Abnabeln – Frauen kompetent beraten

Mortalitas dan Morbiditas pada Bayi Prematur dengan Resusitasi Menggunakan Oksigen Konsentrasi Rendah

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