Achieving blood pressure targets and antihypertensive effects through metabolic surgery in type 2 diabetes patients with hypertension

Abstract

Short Summary This was a prospective study of 535 diabetes patients who underwent metabolic surgery (n = 112) and medical treatment (n = 423). Metabolic surgery decreased both office systolic blood pressure (SBP) and diastolic blood pressure (DBP) and also significantly reduced ambulatory SBP (132 ± 2 vs. 119 ± 1 mmHg, p < 0.0001). Moreover, the rate of achieving the target SBP of 130 and 140 mmHg was also significantly higher in the surgery group. The defined daily dose of antihypertensive medication was significantly decreased in after surgery. Furthermore, metabolic surgery markedly improved the risks of atherosclerotic cardiovascular disease. In conclusion, metabolic surgery can effectively achieve the BP target and improve multiple metabolic dysfunction in type 2 diabetes mellitus patients with hypertension.

Chitosan Nanoparticles in Atherosclerosis—Development to Preclinical Testing

“…Atherosclerosis is responsible for a majority of cardiovascular disease deaths [ 6 , 7 ]. Risk factors or triggers for the disease include high cholesterol, triglyceride and saturated fat levels (mainly through the diet), smoking, high blood pressure, obesity, and reduced or nil physical activity [ 8 , 9 , 10 ].…”

Changes in thyroid hormones predict weight regain in patients with obesity who undergo metabolic surgery

“…Patients with morbid obesity usually exhibit several types of endocrine system disturbances, including insulin resistance, growth hormone resistance and thyroid dysfunction 2 . For patients with morbid obesity, metabolic surgery (MS) is more effective at reducing weight and exerting beneficial effects on metabolism than lifestyle interventions and medication 3–6 . However, weight loss is not sustained after MS; by contrast, weight regain is a common concern and can even occur early and last for many years, resulting in the return of obesity‐associated co‐morbidities and a decrease in the quality of life of the patient 7,8 …”