Achieving clear margins: Review of techniques to more accurately delineate basal cell carcinoma (BCC) macroscopic border prior to excision biopsy

Nagrath, Nalin; Durrani, Amer

doi:10.1016/j.bjps.2018.10.038

Cited by 1 publication

(4 citation statements)

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“…Median age was 66 years (range: 49-83 years) and the lesions were located (number of cases): forehead (2), temple region (3), buccal region (5). The included BCCs consisted of the following subtypes: nodular (8), mixed nodular-superficial (1), morpheaform (1).…”

Section: Resultsmentioning

confidence: 99%

“…The surgical specimen is then assessed by histopathology to determine the outcome (clear/non‐clear margins) and provide additional information about the tumor. To minimize the risk of incomplete excision it is crucial to define the anatomical border of the tumor before surgery; however, the clinical techniques for aiding the margin mapping are very limited 1 . A tumor clearance of 95% can be achieved for small well‐defined BCCs by applying a surgical margin of 4 mm while infiltrative and ill‐defined BCCs usually require greater peripheral margins to achieve similar clearance rates 1 .…”

Section: Introductionmentioning

confidence: 99%

“…To minimize the risk of incomplete excision it is crucial to define the anatomical border of the tumor before surgery; however, the clinical techniques for aiding the margin mapping are very limited 1 . A tumor clearance of 95% can be achieved for small well‐defined BCCs by applying a surgical margin of 4 mm while infiltrative and ill‐defined BCCs usually require greater peripheral margins to achieve similar clearance rates 1 . Therefore, excision with a large safety margin (5–15 mm), multiple mapping biopsies, Mohs micrographic surgery or frozen section analysis are often used to treat these difficult tumors 2,3 .…”

Section: Introductionmentioning

confidence: 99%

“…1 A tumor clearance of 95% can be achieved for small well-defined BCCs by applying a surgical margin of 4 mm while infiltrative and ill-defined BCCs usually require greater peripheral margins to achieve similar clearance rates. 1 Therefore, excision with a large safety margin (5-15 mm), multiple mapping biopsies, Mohs micrographic surgery or frozen section analysis are often used to treat these difficult tumors. 2,3 All of these methods, however, rely on postoperative or ex vivo assessments of tumor margins.…”

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confidence: 99%

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Optical coherence tomography for presurgical delineation of basal cell carcinomas on the face—A comparison with histopathology

et al. 2023

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Background To minimize the risk of incomplete excision of basal cell carcinomas (BCC) the macroscopic tumor margins should be adequately defined. Optical coherence tomography (OCT) is a non‐invasive imaging tool that can provide structural and vascular information about skin cancer lesions. The study objective was to compare the presurgical delineation of facial BCC by clinical examination, histopathology, and OCT imaging in tumors undergoing full excision. Methods Ten patients with BCC lesions on the face were examined clinically, with OCT and histopathology at 3‐mm intervals, from the clinical lesion border and beyond the resection line. The OCT scans were evaluated blinded and a delineation estimate of each BCC lesion was made. The results were compared to the clinical and histopathologic results. Results OCT evaluations and histopathology were in agreement in 86.6% of the collected data points. In three cases the OCT scans estimated a reduction of the tumor size compared to the clinical tumor border set by the surgeon. Conclusion The results of this study support the notion that OCT can have a role in the clinical daily practice by aiding clinicians in delineating BCC lesions before surgery.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%