Achieving control of asthma in preschoolers

Kovesi, Tom; Schuh, Suzanne; Spier, Sheldon; Bérubé, Denis; Carr, Stuart; Watson, Wade; McIvor, R. Andrew

doi:10.1503/cmaj.071638

Cited by 29 publications

(36 citation statements)

References 106 publications

(108 reference statements)

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“…It is more likely that in recent decades there has been an increase in virally triggered wheeze as this is currently the dominant phenotype of preschool asthma. 27 Preschool asthma is believed secondary to smaller airway size at birth or a predilection for airways hyperreactivity triggered by exposure to respiratory viruses. 28 In this case, it remains to be determined what exposures were newly or increasingly present in the environment since the year 1993 onward that increased the susceptibility of children to developing asthma.…”

Section: Discussionmentioning

confidence: 99%

Trends in the age of diagnosis of childhood asthma

Radhakrishnan

Dell

Guttmann

et al. 2014

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Trends in the age of diagnosis of childhood asthma

Radhakrishnan

Dell

Guttmann

et al. 2014

Journal of Allergy and Clinical Immunology

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“…Virus-induced wheezing is prevalent in the preschool years, and symptoms may abate soon afterward. 24,29,30 We would expect low increasing trajectory group with low exacerbation rate to have predominance of children with asthma diagnosed at a younger age. However, the mean age at asthma diagnosis was higher in children in the low increasing trajectory group compared with the mean age at asthma diagnosis in children in the medium decreasing and high decreasing trajectory groups, contrary to our expectation.…”

Section: Discussionmentioning

confidence: 99%

Asthma exacerbation trajectories and their predictors in children with incident asthma

Nasreen

Wilk

Mullowney

et al. 2019

Annals of Allergy, Asthma & Immunology

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Background: Asthma exacerbation trajectories in children after incident asthma diagnosis are understudied. Objective: To identify trajectories of asthma exacerbation and predictors of these trajectories in children with incident asthma. Methods: Children from the National Longitudinal Survey of Children and Youth, Canada, with incident asthma were followed-up for up to 12 years during childhood. Latent class growth modeling was used to identify distinct asthma exacerbation trajectory groups. Multinomial logistic regression was performed to identify predictors of trajectory group membership. Results: The mean age at asthma diagnosis among 403 children was 5.9 years. Three distinct trajectories were identified: low increasing (21.3% of children), medium decreasing (45.8% of children), and high decreasing (32.8% of children). Asthma attack probability increased gradually after diagnosis in low increasing group, decreased from moderate level after diagnosis to almost zero probability at the end of follow-up in the medium decreasing group, and decreased after diagnosis but remained higher in the high decreasing group than the other 2 groups at 12 years after diagnosis. Children having more siblings at home were more likely to belong to the medium decreasing and high decreasing trajectory groups, whereas children older at asthma diagnosis were less likely to belong to the medium decreasing and high decreasing trajectory groups than the low increasing trajectory group. Conclusion: Our results suggest that children with incident asthma follow 3 distinct trajectories of asthma exacerbations after asthma diagnosis. The trajectory group with initial moderate exacerbation probability has better long-term prognosis.

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“…• zdjęcie RTG klatki piersiowej, • morfologię z rozmazem ręcznym, • często konsultację laryngologiczną i/lub alergologiczną [29][30][31][32][33][34][35][36]. Natomiast ciężka, częsta i nie odpowiadająca na leczenie obturacja oskrzeli jest wskazaniem do diagnostyki w specjalistycznych oddziałach szpitalnych.…”

Section: Rozpoznawanie Astmy Wczesnodziecięcejunclassified