Achieving depth-independent lateral resolution in AR-PAM using the synthetic-aperture focusing technique

Gao, Rongkang; Xue, Qiang; Ren, Yongmao; Zhang, Hai; Liu, Song; Liu, Chengbo

doi:10.1016/j.pacs.2021.100328

Cited by 8 publications

(12 citation statements)

References 115 publications

(175 reference statements)

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“…The laser pulse width could also influence the spatial resolution of other PA imaging modalities, such as the lateral resolution in acoustic-resolution PA microscopy (AR-PAM) 60 – 73 and PA computed tomography (PACT), 74 – 86 but the influencing mechanism is different compared with OR-PAM. Due to the employment of diffuse optical illumination, the region of the optical excitation is larger than that of the acoustic detection.…”

Section: Influencing Aspectsmentioning

confidence: 99%

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Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

Gao,

Liu,

et al. 2024

J. Biomed. Opt.

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. Significance In the photoacoustic (PA) technique, the laser irradiation in the time domain (i.e., laser pulse duration) governs the characteristics of PA imaging—it plays a crucial role in the optical-acoustic interaction, the generation of PA signals, and the PA imaging performance. Aim We aim to provide a comprehensive analysis of the impact of laser pulse duration on various aspects of PA imaging, encompassing the signal-to-noise ratio, the spatial resolution of PA imaging, the acoustic frequency spectrum of the acoustic wave, the initiation of specific physical phenomena, and the photothermal–PA (PT-PA) interaction/conversion. Approach By surveying and reviewing the state-of-the-art investigations, we discuss the effects of laser pulse duration on the generation of PA signals in the context of biomedical PA imaging with respect to the aforementioned aspects. Results First, we discuss the impact of laser pulse duration on the PA signal amplitude and its correlation with the lateral resolution of PA imaging. Subsequently, the relationship between the axial resolution of PA imaging and the laser pulse duration is analyzed with consideration of the acoustic frequency spectrum. Furthermore, we examine the manipulation of the pulse duration to trigger physical phenomena and its relevant applications. In addition, we elaborate on the tuning of the pulse duration to manipulate the conversion process and ratio from the PT to PA effect. Conclusions We contribute to the understanding of the physical mechanisms governing pulse-width-dependent PA techniques. By gaining insight into the mechanism behind the influence of the laser pulse, we can trigger the pulse-with-dependent physical phenomena for specific PA applications, enhance PA imaging performance in biomedical imaging scenarios, and modulate PT-PA conversion by tuning the pulse duration precisely.

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Section: Influencing Aspectsmentioning

confidence: 99%

“…The corresponding lateral resolution (0.45 mm) is considerably lower than that of the typical AR-PAM system using a nanosecond-pulsed laser, where

is generally around tens of microns. 1 , 73 , 89 – 91 …”

Section: Influencing Aspectsmentioning

confidence: 99%

Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

Gao,

Liu,

et al. 2024

J. Biomed. Opt.

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“…Photoacoustic imaging (PAI), a promising biomedical technique, achieves superior imaging depths by forming images from optically-derived acoustic signals, which inherently attenuate less than optical signals in biological tissue [ 8 – 10 ]. PAI is based on the photoacoustic (PA) effect, in which energy is converted from light to acoustic waves via thermoelastic expansion [ 11 – 16 ]. To generate PA waves, a laser beam with a typical pulse width of a few nanoseconds illuminates the target tissue.…”

Section: Introductionmentioning

confidence: 99%

Functional photoacoustic imaging: from nano- and micro- to macro-scale

2023

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Functional photoacoustic imaging is a promising biological imaging technique that offers such unique benefits as scalable resolution and imaging depth, as well as the ability to provide functional information. At nanoscale, photoacoustic imaging has provided super-resolution images of the surface light absorption characteristics of materials and of single organelles in cells. At the microscopic and macroscopic scales. photoacoustic imaging techniques have precisely measured and quantified various physiological parameters, such as oxygen saturation, vessel morphology, blood flow, and the metabolic rate of oxygen, in both human and animal subjects. This comprehensive review provides an overview of functional photoacoustic imaging across multiple scales, from nano to macro, and highlights recent advances in technology developments and applications. Finally, the review surveys the future prospects of functional photoacoustic imaging in the biomedical field.

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“…Optical microscopy with extended focal depth has been developed to resolve the out-of-focus problem caused by nonflat samples, and has achieved good results in high-resolution PAM. However, the Bessel beam [30] , [31] and synthetic aperture algorithm [32] have sidelobes, which affect the energy distribution and cause artifacts in the image. The needle-shaped beam method [33] has made breakthrough progress, but it may still be limited by the acoustic focal depth of the transducer, which may require compensation through algorithms.…”

Section: Introductionmentioning

confidence: 99%

Homogeneous-resolution photoacoustic microscopy for ultrawide field-of-view neurovascular imaging in Alzheimer's disease

et al. 2023

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Achieving depth-independent lateral resolution in AR-PAM using the synthetic-aperture focusing technique

Cited by 8 publications

References 115 publications

Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

Influence mechanism of the temporal duration of laser irradiation on photoacoustic technique: a review

Functional photoacoustic imaging: from nano- and micro- to macro-scale

Homogeneous-resolution photoacoustic microscopy for ultrawide field-of-view neurovascular imaging in Alzheimer's disease

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