This paper reports an investigation of the impact of indoor dynamic particle source on the operating strategies of all-air air-conditioning systems using a state-space model. In the case of constant air volume system, the simulation results indicated that if the designed air supply rate was properly determined, the indoor particle concentrations would satisfy the specified requirements of indoor air quality standards. For a variable air volume system, if the strength of indoor particle source is, in a relative sense, large compared to the cooling load, the particle concentrations could markedly increase and would probably bring about indoor air quality problem. The partial load ratio, a dimensionless ratio of the partial source ratio to the partial cooling/heating load ratio, has been suggested as an indicator to guide the design and operation of the air supply rate of variable air volume system. This operating strategy builds on the basis of the identification of indoor sources and takes the relative importance of cooling load and particle sources into the evaluation. The computational results showed that the ventilation performance of variable air volume system was improved by applying the partial load ratio to the operation of variable air volume system.