Achieving higher hierarchical structures by cooperative assembly of tripeptides with reverse sequences

Abstract

Hierarchical self-assembly based on peptides in nature is a multi-component interaction process, providing a broad platform for various bionanotechnological applications. However, the study of controlling the hierarchical structure transformation via...

Self-assembly of glycoprotein nanostructured filaments for modulating extracellular networks at long range

“…54,55 The revealed dynamic/reversibility structures and performances of the hierarchical network structures at a long range might also be useful for designing and programming mesoscopic structural networks for new-generation biomaterial devices. 56–59 Furthermore, the identification of the major hierarchical structures driven by physiological needs to induce specific complex architectures, not of random organization, guarantees control over the extracellular network of macroscopic structures, especially for the relevant outer profile having the first impact with the external biological identity. 60 Furthermore, the novel structural approaches adopted here not only give us the advantage of characterizing self-assembling glycoprotein surface/networks but also the feasibility of applying these morpho-structural studies to any complex system, independently of the dimension scale.…”

Designing Pathway-Controlled Multicomponent Ultrashort Peptide Hydrogels with Diverse Functionalities at the Nanoscale for Directing Cellular Behavior

“…Despite displaying diverse structural and physicochemical properties, the biological applications of short-peptide hydrogels based on a single type of gelator molecule is limited due to their weak mechanical properties and lack of chemical as well as functional diversity arising from a single-molecular domain. , An interesting way to enhance the mechanical, structural, and functional characteristics is by nanoengineering a 3D fibrous network through molecular coassembly of two or more functional peptide building blocks. − Coassembly of two or more peptides with surfactants, polymers, or other aromatic peptide amphiphiles having distinct functionalities can result in nanostructures with synergistically combined properties of both the coassembling entities. − In this context, several eminent research groups of Ulijn, Reches, Gazit, and Adler-Abramovich have emphasized that the incorporation of a coassembly approach has resulted in enhanced control over the nanostructures along with the possibility of generating new materials with emergent properties. ,,,,− This approach has led to the formation of superior materials with diverse morphologies and tunable mechanical properties coupled with improved cell–matrix interactions. ,,,,− , Moreover, the application of coassembled hydrogels in drug delivery, wound healing, light harvesting, and in inverting the supramolecular chirality has also been reported. − …”