Achieving long-term stability of thin-film electrodes for neurostimulation

Oldroyd, Poppy; Malliaras, George G.

doi:10.1016/j.actbio.2021.05.004

Cited by 53 publications

(60 citation statements)

References 188 publications

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“…This comes from the poor adhesion properties of such materials on the top of metal layers in aqueous conditions, even more pronounced under stimulation. Future approaches may overcome those technological limitations, as for instance using biostable adhesion promoters [61]. Fibrosis was not investigated in our study although this problem (as well as other nerve damage) has been reported with commonly used metallic electrodes.…”

Section: Acute Eng Recordings With Oementioning

confidence: 97%

Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection

Avdeew

Bergé-Laval

Rolle

et al. 2021

Sensors

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Effective closed-loop neuromodulation relies on the acquisition of appropriate physiological control variables and the delivery of an appropriate stimulation signal. In particular, electroneurogram (ENG) data acquired from a set of electrodes applied at the surface of the nerve may be used as a potential control variable in this field. Improved electrode technologies and data processing methods are clearly needed in this context. In this work, we evaluated a new electrode technology based on multichannel organic electrodes (OE) and applied a signal processing chain in order to detect respiratory-related bursts from the phrenic nerve. Phrenic ENG (pENG) were acquired from nine Long Evans rats in situ preparations. For each preparation, a 16-channel OE was applied around the phrenic nerve’s surface and a suction electrode was applied to the cut end of the same nerve. The former electrode provided input multivariate pENG signals while the latter electrode provided the gold standard for data analysis. Correlations between OE signals and that from the gold standard were estimated. Signal to noise ratio (SNR) and ROC curves were built to quantify phrenic bursts detection performance. Correlation score showed the ability of the OE to record high-quality pENG. Our methods allowed good phrenic bursts detection. However, we failed to demonstrate a spatial selectivity from the multiple pENG recorded with our OE matrix. Altogether, our results suggest that highly flexible and biocompatible multi-channel electrode may represent an interesting alternative to metallic cuff electrodes to perform nerve bursts detection and/or closed-loop neuromodulation.

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Section: Acute Eng Recordings With Oementioning

confidence: 97%

Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection

Avdeew

Bergé-Laval

Rolle

et al. 2021

Sensors

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“…In general, a conduction current across an EFS structure must be related with an electrochemical reaction at the ferroelectric/electrolyte interface, i.e., a reducing reaction with electrons or an oxidizing reaction with holes in combination with a redox system in the electrolye with a suitable level of the redox potential [17,18]. It should be noted, that conduction currents are undesired for neural stimulation with ferroelectric microelectrodes, since they can affect safety and long-term stability [7,13]. For BTO, it is known that oxygen vacancies O o can act as donors of free electrons e − which induce n-type conductivity [31].…”

Section: B Device Characterizationmentioning

confidence: 99%

“…For neural stimulation with ferroelectric microelectrodes, resistive switching behavior is undesired since electrochemical charge transport (conduction current J c ) across the ferroelectric/electrolyte interface may negatively affect long-term stability [7,13]. However, resistive switching behavior of two-terminal EFS devices could be exploited for extracellular recording in hybrid neurocomputational systems: a biological neuron can be cultivated on the active area of the EFS device and the extracellular voltage generated by an action potential of the neuron acts as driving voltage to change the resistance state of the EFS device.…”

Section: B Device Characterizationmentioning

confidence: 99%

“…Since then, bioelectronic interfacing with conductive microelectrodes has been intensively studied, resulting in a widespread utilization for in-vitro and in-vivo applications [2][3][4][5]. However, it is difficult to avoid toxic electrochemical effects (Faradaic currents) at the conductive microelectrode/electrolyte interface, which may result in corrosion of electrodes and cell or tissue damage [6] and detrimentally affects longterm stability of neural implants [7].…”

Section: Introductionmentioning

confidence: 99%

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Ferroelectricity and resistive switching in BaTiO$_3$ thin films with liquid electrolyte top contact for bioelectronic devices

Becker¹,

Oldroyd²,

Strkalj³

et al. 2022

Preprint

Self Cite

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We investigate ferroelectric-and resistive switching behavior in 18-nm-thick epitaxial BaTiO3 (BTO) films in a model electrolyte-ferroelectric-semiconductor (EFS) configuration. The system is explored for its potential as a ferroelectric microelectrode in bioelectronics. The BTO films are grown by pulsed laser deposition (PLD) on semiconducting Nb-doped (0.5 wt%) SrTiO3 (Nb:STO) single crystal substrates. The ferroelectric properties of the bare BTO films are demonstrated by piezoresponse force microscopy (PFM) measurements. Cyclic voltammetry (CV) measurements in EFS configuration, with phosphate buffered saline (PBS) acting as the liquid electrolyte top contact, indicate characteristic ferroelectric switching peaks in the bipolar current-voltage loop. The ferroelectric nature of the observed switching peaks is confirmed by analyzing the current response of the EFS devices to unipolar voltage signals. Moreover, electrochemical impedance spectroscopy (EIS) measurements indicate bipolar resisitive switching behavior of the EFS devices, which is controlled by the remanent polarization state of the BTO layer. Our results represent a constitutive step towards the realization of neuroprosthetic implants and hybrid neurocomputational systems based on ferroelectric microelectrodes.

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“…Considering the need for continuous and prolonged operation, comfort, wearability, reusability, and robustness, sensors based on dry electrodes are generally preferred as advanced human–robot interfaces for applications that do not involve severe disabilities. − The development of hydrogel-based noninvasive electrodes reduced the amount of necessary gel/paste; however, the sensors retain some of the limitations of the wet sensors . Some of the currently available dry EEG sensors are based on metal pins for contact on hairy areas or on foam sensors covered by a highly conductive metal mesh. , None of these solutions offer sufficient performance and therefore are one of the elements holding back the development of efficient brain–machine interface technologies. ,,, …”

Section: Introductionmentioning

confidence: 99%

Thin-Film Electrodes Based on Two-Dimensional Nanomaterials for Neural Interfaces

Faisal

Iacopi

2022

ACS Appl. Nano Mater.

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Detection and monitoring of neural signals is a fastadvancing area of research expected to impact a broad range of advanced applications, from healthcare to brain−machine and even brain-to-brain communications. Two-dimensional (2D) layered materials, such as graphene, MXenes, and transition metal dichalcogenides, could lead to the development of superior and ultrathin thin-film electrodes for neural interfaces thanks to their atomic thickness, high-conductivity properties, and potential to combine additional functionalities. This review focuses on the recent advancement of 2D materials-based thin-film sensors for monitoring of bio-physiological signals using invasive and noninvasive approaches.

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Achieving long-term stability of thin-film electrodes for neurostimulation

Cited by 53 publications

References 188 publications

Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection

Assessment of the Use of Multi-Channel Organic Electrodes to Record ENG on Small Nerves: Application to Phrenic Nerve Burst Detection

Ferroelectricity and resistive switching in BaTiO$_3$ thin films with liquid electrolyte top contact for bioelectronic devices

Thin-Film Electrodes Based on Two-Dimensional Nanomaterials for Neural Interfaces

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