With the rapid development of the aerospace, automobile, and ocean industries, there is an urgent need for the fabrication of high-performance polymer matrix composites with low friction and wear in wide temperature ranges. In this paper, polytetrafluoroethylenes (PTFEs) doped with polyether-ether-ketone (PEEK), carbon fiber (CF), and TiC were prepared, and the effects of testing temperatures from room temperature to 250 °C in air conditions were investigated. The results showed that the friction coefficient of the PTFE matrix composites had no obviously changing trend, while the wear resistance properties were significantly improved. Due to the synergistic lubrication and enhancement of CF, PEEK, and TiC, the wear rate for composites with these particles decreased from (2.04–2.72) × 10−3 mm3/Nm for pure PTFE to (0.67–1.96) × 10−4 mm3/Nm. Moreover, the SEM analysis results showed that the main wear mechanisms are fatigue and abrasive wear for the PTFE matrix composites. The results obtained in this study will provide data and technical support for the development of high-performance polymer matrix composites with low friction and wear that can be used over a wide temperature range.