Achiral–chiral LC/LC–MS/MS coupling for determination of chiral discrimination effects in phenprocoumon metabolism

Kammerer, Bernd; Kahlich, Rainer; Ufer, Mike; Laufer, Stefan; Gleiter, Christoph H.

doi:10.1016/j.ab.2005.01.010

Cited by 18 publications

(10 citation statements)

References 48 publications

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“…Kammerer et al . () (Table ) describe a novel two‐dimensional on‐line achiral coupling by using a peak parking technique in combination with a makeup flow system. Phenprocoumon and its metabolites were separated in the first dimension using a C 18 reversed‐phase system.…”

Section: Multidimensional Liquid Chromatography In Chiral Analysismentioning

confidence: 97%

“…Kammerer et al . () have studied the metabolism of xenobiotics as catalyzed by cytochrome P450 enzymes. A two‐dimensional on‐line achiral–chiral liquid chromatography–tandem mass spectrometry coupling method was developed using a peak parking technique in combination with a make‐up flow system.…”

Section: Multidimensional Liquid Chromatography In Chiral Analysismentioning

confidence: 97%

“…Different interface designs with trapping capabilities have been described in the literature (Tables and ). One of the possibilities is the use of loops, either empty (Hamase et al ., ) or packed with stationary phase (Welsch et al ., ; Kammerer et al ., ). The interface is, in this case, responsible for the collection and temporary storage of the fractions, after which the analytes are released towards the secondary column.…”

Section: Multidimensional Liquid Chromatography In Chiral Analysismentioning

confidence: 99%

“…The synthesis of optically active polymers is an important area in macromolecular science, as they have a wide variety of potential applications, including the preparation of CSPs. Kammerer et al (2005) ( Table 2) describe a novel two-dimensional on-line achiral coupling by using a peak parking technique in combination with a makeup flow system. Phenprocoumon and its metabolites were separated in the first dimension using a C 18 reversed-phase system.…”

Section: Stationary Phasesmentioning

confidence: 99%

See 3 more Smart Citations

Two‐dimensional liquid chromatography for direct chiral separations: a review

León-González

Rosales-Conrado

Pérez-Arribas

et al. 2013

Biomedical Chromatography

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Separation of enantiomers remains a challenge owing to their identical physical and chemical properties in an achiral environment, and research on specialized separation techniques such as multidimensional achiral-chiral liquid chromatography continues to resolve individual enantiomers in complex samples. Recent advances in application of multidimensional liquid chromatography applied to chiral analysis are reviewed. For this reason, benefits of achiral-chiral coupling are shown, with emphasis in applications on biological and pharmaceutical fields as well as pesticide analysis. A description of standard instrumental setup in both heart-cut and comprehensive multidimensional liquid chromatography is shown. The most broadly used chiral stationary phases for multidimensional liquid chromatography are summarized. An extensive overview of different interface designs applied to complex samples is presented.

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Section: Multidimensional Liquid Chromatography In Chiral Analysismentioning

confidence: 97%

Section: Multidimensional Liquid Chromatography In Chiral Analysismentioning

confidence: 97%

Section: Multidimensional Liquid Chromatography In Chiral Analysismentioning

confidence: 99%

Section: Stationary Phasesmentioning

confidence: 99%

See 2 more Smart Citations

Two‐dimensional liquid chromatography for direct chiral separations: a review

León-González

Rosales-Conrado

Pérez-Arribas

et al. 2013

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…For enantioseparation, a peak parking method has been demonstrated, where plasma metabolites were first separated by a RP method, then stored on a series of cartridges, before back flushing onto an analytical enantioselective stationary phase with MS detection (Kammerer et al, 2005).…”

Section: Hplc-based Methodsmentioning

confidence: 99%

Comprehensive multi‐dimensional liquid chromatographic separation in biomedical and pharmaceutical analysis: a review

Dixon

Pitfield

Perrett

2006

Biomedical Chromatography

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‘Multi‐dimensional’ liquid separations have a history almost as long as chromatography. In multi‐dimensional chromatography the sample is subjected to more than one separation mechanism; each mechanism is considered an independent separation dimension. The separations can be carried out either offline via fraction collection, or directly coupled online. Early multi‐dimensional separations using combinations of paper chromatography, electrophoresis and gels, in both planar and columnar modes are reviewed. Developments in HPLC have increased the number of measurable analytes in ever more complex matrices, and this has led to the concept of ‘global metabolite profiling’. This review focuses on the theory and practice of modern ‘comprehensive’ multi‐dimensional liquid chromatography when applied to biomedical and pharmaceutical analysis. Copyright © 2006 John Wiley & Sons, Ltd.

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Current literature in mass spectrometry

2005

J. Mass Spectrom.

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of mass spectrometry. Each bibliography is divided into 11 sections: 1 Books, Reviews & Symposia; 2 Instrumental Techniques & Methods; 3 Gas Phase Ion Chemistry; 4 Biology/Biochemistry: Amino Acids, Peptides & Proteins; Carbohydrates; Lipids; Nucleic Acids; 5 Pharmacology/Toxicology; 6 Natural Products; 7 Analysis of Organic Compounds; 8 Analysis of Inorganics/Organometallics; 9 Surface Analysis; 10 Environmental Analysis; 11 Elemental Analysis. Within each section, articles are listed in alphabetical order with respect to author (5 Weeks journals ‐ Search completed at 10th. Aug. 2005)

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Achiral–chiral LC/LC–MS/MS coupling for determination of chiral discrimination effects in phenprocoumon metabolism

Cited by 18 publications

References 48 publications

Two‐dimensional liquid chromatography for direct chiral separations: a review

Two‐dimensional liquid chromatography for direct chiral separations: a review

Comprehensive multi‐dimensional liquid chromatographic separation in biomedical and pharmaceutical analysis: a review

Current literature in mass spectrometry

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